Expression and clinical significance of stem cell marker CD133 in human neuroblastoma.

World Journal of Pediatrics : WJP
Qiang-Song TongJia-Bin Cai

Abstract

Recent evidences indicate that CD133, a kind of transmembrane protein, can be used as a marker to isolate stem cells from tumors originating from neural crest. This study was undertaken to explore the expression and clinical significance of stem cell marker CD133 in neuroblastoma (NB). Immunohistochemical staining was used to detect the expression of CD133 in 32 patients with NB and 8 patients with ganglioneuroblastoma (GNB). The relationships were analyzed among CD133 expression, international neuroblastoma staging system (INSS) stages, pathological classification, and postoperative survival time of NB patients. The expression rates of CD133 in NB and GNB were 46.9% (15/32) and 37.5% (3/8) respectively, mainly in cytoplasm of neuroblastoma cells. The expression rates of stage 1-2, stage 3-4 and stage 4S were 30.7%, 57.9% and 37.5%, respectively. The differences in various stages were significant (P<0.05). The positive rate of CD133 in patients with unfavorable histology (52.4%) was significantly higher than that in patients with favorable histology (36.8%) (P=0.007). The survival time of CD133 negative patients was significantly longer than that of CD133 positive patients (P=0.026). CD133 which might be correlated with the dev...Continue Reading

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Citations

Aug 21, 2009·World Journal of Pediatrics : WJP·Li-Duan ZhengJia-Bin Cai
Sep 25, 2009·Glycobiology·Yoshihiko NakataniRobert K Yu
Jan 20, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Sagar DhamneNina Tatevian
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Jul 20, 2013·Brain Pathology·Shawn L Hervey-JumperSandra Camelo-Piragua
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Jun 28, 2011·The American Journal of Pathology·Liat Edry BotzerIsaac P Witz
Nov 29, 2014·World Journal of Pediatrics : WJP·Li-Li XingFan Lv
Mar 12, 2011·Cancers·Gregory K Friedman, G Yancey Gillespie
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