Expression and clinical significance of Wnt players and survivin in pituitary tumours.

Endocrine Pathology
Robert FormosaJosanne Vassallo

Abstract

Deregulation of the Wnt pathway has been implicated in oncogenesis of numerous tissues including the pituitary gland. Immunohistochemical localization and quantification of β-catenin, Cyclin D1, c-MYC and Survivin expression in 47 pituitary adenomas (35 non-functioning, seven GH-secreting, three prolactinomas, two ACTH-secreting tumour) and six normal controls was undertaken in this study and correlation of protein expression to patient and tumour characteristics analysed. β-catenin was strictly membrane-bound with no difference observed between normal and tumour tissue. In contrast, Cyclin D1 and c-MYC localization was nuclear and significantly higher in tumour versus normal tissue (p < 0.05). c-MYC expression correlated negatively with age at diagnosis (p = 0.006, R = -0.395) while Cyclin D1 expression correlated positively with age (p = 0.036, R = 0.306) and was higher in males than in females (p = 0.036). c-MYC expression was significantly lower in patients with functional tumours requiring octreotide treatment and in patients with non-functioning tumours suffering from hypopituitarism. Survivin expression was extremely low in tumours and absent in normal controls. Involvement of the canonical Wnt pathway appears to be mini...Continue Reading

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Citations

May 22, 2013·Endocrine-related Cancer·T J G ChambersJ R E Davis
May 25, 2013·Endocrine-related Cancer·R FormosaJ Vassallo
Jun 28, 2015·Annales d'endocrinologie·Christine Cortet-RudelliPhilippe Chanson
Aug 12, 2014·Pituitary·Joanna Waligórska-StachuraMarek Ruchała
May 23, 2014·Molecular and Cellular Endocrinology·R Formosa, J Vassallo
Jun 27, 2017·Endocrine-related Cancer·R FormosaJ Vassallo
Oct 19, 2017·Pathology Oncology Research : POR·O DarvasiHenriett Butz

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