Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer

Clinical Colorectal Cancer
Elisabeth OdinBengt Gustavsson

Abstract

The aim of the study was to investigate the influence of methylenetetrahydrofolate reductase (MTHFR) gene expression levels and MTHFR polymorphism C677T on the outcome of patients with colorectal cancer (CRC). Furthermore, we wanted to evaluate the interaction between MTHFR and thymidylate synthase (TS) and folylpolyglutamate synthase (FPGS) and to investigate the impact of folate concentration on patients with CRC with different MTHFR genotypes. The frequency of MTHFR polymorphism C677T was determined (n = 147), and gene expression levels of MTHFR, TS, and FPGS were quantified with real-time polymerase chain reaction (n = 157). Reduced folates in tissue were measured with a binding assay (n = 40). We observed a significantly lower concentration of tetrahydrofolate (THF) in patients with CT or TT genotypes compared with patients having the CC genotype. Twenty-six patients with Dukes A to C tumors who had not been subjected to chemotherapy relapsed. Out of these, 18 had CT or TT genotypes, and only 8 had the CC genotype (P = 0.045). Furthermore, 75 patients did not relapse, and out of these, 35 had CT or TT genotypes, and 40 had the CC genotype. The relative gene expression level of MTHFR in patients subgrouped by CC and CT or T...Continue Reading

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Citations

Feb 11, 2009·Clinical Colorectal Cancer·Kristoffer DerwingerBengt Gustavsson
Mar 28, 2009·International Journal of Cancer. Journal International Du Cancer·Barry IacopettaLin Fritschi
Mar 7, 2014·Clinical Medicine Insights. Oncology·Helena TaflinKristoffer Derwinger
Nov 24, 2007·Pharmacogenomics·Marie-Christine Etienne-GrimaldiGérard Milano
May 27, 2017·Journal of Digestive Diseases·Yu Ling ShenHong Tu
Mar 26, 2011·Journal of Intensive Care Medicine·Christian ConsilvioGeoffrey K Lighthall
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marcus SchlemmerMarcus Hentrich

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