Expression and correlation of Bcl-2 with pathological grades in human glioma stem cells

Oncology Reports
Bo QiuYunjie Wang

Abstract

The anti-apoptotic gene, B-cell lymphoma-2 (Bcl-2), has been reported to be overexpressed in gliomas and is related to tumor prognosis, suggesting a potential therapeutic target. Additionally, recent studies have demonstrated the existence of brain glioma stem cells (BGSCs) which are tumorigenic, self-renewable and dominate the biological behavior of gliomas. Currently BGSCs are committed as a new target of glioma therapies. However, few studies have focused on the expression of Bcl-2 in BGSCs. We performed a series of experiments to culture BGSCs from eight clinical specimens, followed by real-time RT-PCR and immunoassays to compare the expression levels of Bcl-2 in BGSCs and their corresponding primary glioma cells (PGCs). The results showed that Bcl-2 mRNA and protein expression levels are higher in BGSCs compared to their counterparts, and the expression levels are related to glioma malignancies. As an anti-apoptotic gene, Bcl-2 assigns immortality characteristics to cells, which coincide with the pivotal biological feature of BGSCs. The experimental results indicated that BGSCs would evade apoptosis for higher Bcl-2 expression, and may interpret the drug resistance of glioma to cytotoxic drugs and other pro-apoptotic agent...Continue Reading

Citations

Dec 16, 2016·International Journal of Molecular Sciences·Yun-Jung ChoiSangiliyandi Gurunathan
Dec 21, 2017·BioMed Research International·Silvia Anahi Valdés-RivesAliesha González-Arenas
Dec 3, 2017·Journal of Neuro-oncology·Eric GoetheNaveen Pemmaraju
Sep 1, 2021·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·I V ChekhoninI N Pronin

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