Abstract
It has been suggested that xenoestrogens, a group of agents termed endocrine disruptors, may contribute to the development of hormone-dependent cancers, such as breast and endometrial cancers. We previously demonstrated that the xenoestrogen, bisphenol A (BPA), was able to induce the transformation in vitro of human breast epithelial cells. The normal-like human breast epithelial cell line, MCF-10F, formed tubules in collagen (3-D cultures), although after treatment with BPA (10-5 M and 10-6 M BPA) the cells produced less tubules (73% and 80%, respectively) and some spherical masses (27% and 20%, respectively). In the present study, expression and DNA methylation analyses were performed in these cells after exposure to BPA. These cells showed an increased expression of BRCA1, BRCA2, BARD1, CtIP, RAD51 and BRCC3, all of which are genes involved in DNA repair, as well as the downregulation of PDCD5 and BCL2L11 (BIM), both of which are involved in apoptosis. Furthermore, DNA methylation analysis showed that the BPA exposure induced the hypermethylation of BCL2L11, PARD6G, FOXP1 and SFRS11, as well as the hypomethylation of NUP98 and CtIP (RBBP8). Our results indicate that normal human breast epithelial cells exposed to BPA have in...Continue Reading
References
Jun 1, 1992·Carcinogenesis·S SteinerP Sagelsdorff
Feb 1, 1989·Carcinogenesis·P BentleyF Waechter
May 16, 1995·Biochemical and Biophysical Research Communications·A Atkinson, D Roy
Dec 1, 1996·Nature Genetics·L C WuR Baer
Aug 15, 1997·Analytical Chemistry·K VanhoutteA J Hudson
Feb 28, 1998·The EMBO Journal·L O'ConnorD C Huang
Dec 2, 1999·Endocrine Journal·S MaruyamaA Ito
Mar 4, 2000·Endocrine Reviews·J G Liehr
Aug 5, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C X Deng, S G Brodie
Aug 31, 2000·The Journal of Biological Chemistry·E J RoutledgeJ P Sumpter
Mar 22, 2001·Chemical Research in Toxicology·J B MatthewsT R Zacharewski
Feb 28, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Patrick DielHorst Michna
Oct 29, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kazuyuki Ouchi, Shaw Watanabe
Oct 31, 2002·Human Reproduction·Yumiko IkezukiYuji Taketani
Dec 18, 2002·The EMBO Journal·Donna L MalleryKevin Hiom
Dec 31, 2002·Toxicology·K C ChitraP P Mathur
Mar 1, 2003·Nature Genetics·Rudolf Jaenisch, Adrian Bird
Apr 25, 2003·Archives of Environmental Contamination and Toxicology·Mihi YangYoon-Ok Ahn
Jul 31, 2003·Food Additives and Contaminants·C BredeH Herikstad
Aug 20, 2003·Biostatistics·Rafael A IrizarryTerence P Speed
Oct 16, 2004·Molecular and Cellular Biology·Xiaochun Yu, Junjie Chen
Jul 12, 2005·Nature Genetics·Michael WeberDirk Schübeler
Jul 21, 2005·Environmental Research·David W SingletonSohaib A Khan
Aug 17, 2005·Biochemistry·Ashok K VarmaJohn A A Ladias
Sep 15, 2005·Cancer Letters·Christine L PowellIvan Rusyn
Jan 18, 2006·Chemical Research in Toxicology·Muhammad ZahidErcole Cavalieri
May 6, 2006·Biochimica Et Biophysica Acta·Ercole CavalieriThomas Sutter
May 13, 2006·Endocrinology·Wade V WelshonsFrederick S vom Saal
Jun 3, 2006·Cancer Research·Shuk-Mei HoGail S Prins
Jul 29, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jose RussoIrma H Russo
Aug 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·W Evan JohnsonX Shirley Liu
Nov 23, 2006·DNA Repair·Tapas K HazraRabindra Roy
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dana C DolinoyRandy L Jirtle
Nov 1, 2007·International Journal of Andrology·Ana M SotoCarlos Sonnenschein
Apr 3, 2008·Cancer Research·Shanaz H DairkeeWilliam H Goodson
Nov 4, 2008·Nature Biotechnology·Hongkai JiWing H Wong
Aug 4, 2009·Cell Biology International·Hilal KocdorSandra V Fernandez
Aug 8, 2009·Mutation Research·Alberto IzzottiSilvio De Flora
Nov 26, 2009·Toxicologic Pathology·S V Fernandez, J Russo
Oct 15, 2010·IUBMB Life·Ercole L Cavalieri, Eleanor G Rogan
Citations
Sep 26, 2013·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Pedro Martínez-PazGloria Morcillo
Jan 18, 2013·PloS One·Jie ZhangNa Niu
Mar 19, 2014·Environmental Toxicology and Pharmacology·Jaromir Michałowicz
Sep 11, 2014·International Journal of Molecular Sciences·Edna Ribeiro-VarandasMargarida Delgado
Jul 24, 2014·International Journal of Environmental Research and Public Health·Guergana MilevaCatherine Bielajew
Mar 21, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Nivedita ChatterjeeJinhee Choi
Dec 30, 2015·Toxicology and Applied Pharmacology·Manon C BouwmeesterLeo T M van der Ven
Mar 8, 2014·Cell Biology International·Yuka NishimuraNobuyuki Fukushima
Sep 3, 2013·Reproductive Toxicology·Johanna R Rochester
Oct 4, 2014·General and Comparative Endocrinology·Ramji K BhandariCheryl S Rosenfeld
May 5, 2016·Molecular Nutrition & Food Research·Donato F RomagnoloOrnella I Selmin
Feb 19, 2015·PloS One·Natalie R GassmanSamuel H Wilson
Feb 10, 2017·Environmental and Molecular Mutagenesis·Natalie R Gassman
Jan 24, 2017·Molecular and Cellular Endocrinology·Danila CuomoConcetta Ambrosino
Mar 23, 2017·International Journal of Environmental Research and Public Health·Maddalena MallozziDonatella Caserta
Oct 21, 2017·Toxics·Edna RibeiroSusana Viegas
Feb 28, 2020·Environmental Health Perspectives·Zhe LiHailin Wang
May 15, 2018·Oncotarget·Manosij GhoshPeter H M Hoet
Dec 2, 2017·Oncotarget·Bin LiuYuping Gao
May 3, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lin HuiYihua Wu
May 30, 2020·International Journal of Molecular Sciences·Vidhya A NairWael M Abdel-Rahman
Apr 23, 2020·International Journal of Environmental Research and Public Health·Jin Hee Kim, Yun-Chul Hong
Mar 19, 2020·Clinical Interventions in Aging·Mojgan SheikhpourTohid Seif Barghi
May 12, 2018·Scientific Reports·Vera A van der WeijdenSusanne E Ulbrich
Sep 25, 2019·Cancers·Nora JungBoris Guyot
Oct 4, 2020·BMC Cancer·Gita A PathakNicole R Phillips
Mar 6, 2021·Environmental Science and Pollution Research International·Nadeem Ghani KhanShama Prasada Kabekkodu
Apr 13, 2021·Journal of Cancer Prevention·Cassandra Winz, Nanjoo Suh
May 26, 2018·Chemical Research in Toxicology·Manoj SonavaneNatalie R Gassman