PMID: 11304714Apr 17, 2001

Expression and estrogen regulation of brain-derived neurotrophic factor gene and protein in the forebrain of female prairie voles

The Journal of Comparative Neurology
Y LiuZ Wang


Brain-derived neurotrophic factor (BDNF) has been linked to the development, differentiation, and plasticity of the central nervous system. In the present study, we first used a highly specific affinity-purified antibody and a cRNA probe to generate a detailed mapping of BDNF immunoreactive (BDNF-ir) staining and mRNA labeling throughout the forebrain of female prairie voles. Our data revealed that (1) BDNF-ir cells were present essentially in the brain regions in which BDNF mRNA-labeled cells were found; (2) BDNF-ir fibers were distributed extensively throughout many forebrain regions; and (3) BDNF mRNA was also detected in some thalamic regions in which BDNF-ir fibers, but not immunostained cells, were present. With few exceptions, the distribution pattern of BDNF in the vole brain generally resembled the pattern found in rats. In a second experiment, we examined the effects of estrogen on BDNF expression. Ovariectomized prairie voles that were treated with estradiol benzoate had a higher level of BDNF mRNA labeling in the dentate gyrus and CA3 region of the hippocampus, as well as in the basolateral nucleus of the amygdala, than did ovariectomized voles that were treated with vehicle. In addition, estrogen treatment increase...Continue Reading


Dec 16, 2004·Behavioral Neuroscience·Stephanie M Fernandez, Karyn M Frick
Mar 26, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Faqi WangJunsheng Ma
Jul 28, 2010·Behavioural Pharmacology·Sonali LokugeMeir Steiner
May 18, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shau-Ming WeiKaren F Berman
Oct 1, 2013·Brain & Development·Xiu-Juan LiHeng-Sheng Chen
Jul 28, 2004·International Review of Psychiatry·J L Payne
Sep 4, 2007·Brain Research Reviews·Christie D FowlerZuoxin Wang
Oct 31, 2006·Frontiers in Neuroendocrinology·F Sohrabji, Danielle K Lewis
Jul 20, 2005·The European Journal of Neuroscience·Konrad LehmannGertraud Teuchert-Noodt
Nov 16, 2004·Annals of the New York Academy of Sciences·Dean E Dluzen, J L McDermott
May 29, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Amanda P Borrow, Nicole M Cameron
Jun 6, 2013·Environmental Toxicology and Pharmacology·Xiu-Juan LiXin Li
Feb 11, 2015·Human Reproduction·Jocelyn M WesselsWarren G Foster
Apr 5, 2002·Journal of Neurobiology·Christie D FowlerZuoxin Wang
Nov 11, 2003·Journal of Neurobiology·Christie D FowlerZuoxin Wang
Nov 30, 2006·Journal of Neuroscience Research·M C OsborneD R Sengelaub
Nov 1, 2002·The Journal of Comparative Neurology·Veronique G J M VanderhorstHenry J Ralston
Jun 28, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jill B Becker, Elena Chartoff
Aug 13, 2020·Biomolecules·Claudia Jorgensen, Zuoxin Wang


May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C D Toran-AllerandN J MacLusky
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C WetmoreL Olson
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B KnüselF Hefti
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G F JirikowskiF E Bloom
Jan 1, 1987·Physiology & Behavior·M Cohen-Parsons, C S Carter
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·F SohrabjiC D Toran-Allerand
May 1, 1994·Trends in Neurosciences·R M LindsayP S DiStefano
Aug 1, 1994·Journal of Neurobiology·F SohrabjiC D Toran-Allerand
Oct 27, 1995·Science·H Thoenen
Jul 1, 1995·Trends in Neurosciences·M V Chao, B L Hempstead
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·B Kirschenbaum, S A Goldman
Oct 1, 1994·Journal of Neuroscience Methods·R R Mize
Sep 1, 1995·The European Journal of Neuroscience·M M Dugich-DjordjevicF Hefti
Jan 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·C D Toran-Allerand
May 15, 1997·Journal of Neuroscience Research·M J SchaafE Vreugdenhil
Dec 5, 1997·Brain Research. Molecular Brain Research·B ConnorM Dragunow
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·D D MurphyM Segal
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·E Akutagawa, M Konishi

Related Concepts

Estradiol, (16 alpha,17 beta)-Isomer
Recombinant Brain-Derived Growth Factors
Brain-Derived Neurotrophic Factor Measurement
Entire Central Nervous System
Sexual Behavior, Animal

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.