Expression and function of a CD4-like molecule in parathyroid tissue

Surgery
P HellmanC Juhlin

Abstract

Parathyroid tissue expresses the T-lymphocyte antigens CD3 and CD4, and parathyroid CD3 has earlier been proposed to interact in the regulation of parathyroid hormone (PTH) release. Anti-Leu3a, a monoclonal antibody recognizing CD4, was used to stain parathyroid tissue immunohistochemically, to influence PTH secretion from enzymatically dispersed parathyroid cells, and to immunoprecipitate parathyroid CD4. Northern blot and polymerase chain reaction were used to clarify the similarity between parathyroid and lymphocytic CD4. Serum PTH level was measured with an immunoradiometric assay in healthy control subjects and individuals with human immunodeficiency virus type 1. The parenchyma of normal and abnormal parathyroid tissue displayed strikingly variable CD4 expression. Immunoprecipitation showed a 56 kd molecule, and Northern blot and polymerase chain reaction confirmed the similarity with lymphocyte CD4. Anti-Leu3a inhibited preferentially low calcium-stimulated secretion of PTH from dispersed parathyroid cells, without discernible influences on the cytoplasmic calcium concentration of these cells. Individuals with human immunodeficiency virus type 1 displayed significantly lower serum PTH levels than healthy control subjects...Continue Reading

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Citations

Jun 30, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E M SteinE Shane
Mar 30, 1999·Journal of Internal Medicine·E W KuehnD Schlöndorff
Dec 4, 2012·AIDS Research and Human Retroviruses·Ulrich Christian BangJens-Erik Beck Jensen
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C A KühneL C Hofbauer
Aug 30, 2005·The Journal of Infection·John Williams, David R Chadwick
Mar 4, 2014·Journal of Thyroid Research·Rabia CherqaouiVinod Mody
Mar 7, 2000·Clinical and Diagnostic Laboratory Immunology·G M Graziani-Bowering, L G Filion
Oct 26, 2018·Case Reports in Endocrinology·Sartaj SandhuAjay Chaudhuri
Jul 5, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Joegi Thomas, Sheelagh M Doherty

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