Expression and function of macrophage-inducible C-type lectin (Mincle) in inflammation driven parturition in fetal membranes and myometrium

Clinical and Experimental Immunology
R Lim, M Lappas

Abstract

The pivotal role of inflammatory processes in human parturition is well known, but not completely understood. We have performed a study to examine the role of macrophage-inducible C-type lectin (Mincle) in inflammation-associated parturition. Using human samples, we show that spontaneous labour is associated with up-regulated Mincle expression in the myometrium and fetal membranes. Mincle expression was also increased in fetal membranes and myometrium in the presence of pro-labour mediators, the proinflammatory cytokines interleukin (IL)-1B and tumour necrosis factor (TNF), and Toll-like receptor (TLR) ligands fsl-1, poly(I:C), lipopolysaccharide (LPS) and flagellin. These clinical studies are supported by mouse studies, where an inflammatory challenge in a mouse model of preterm birth increased Mincle expression in the uterus. Importantly, elimination of Mincle decreased the effectiveness of proinflammatory cytokines and TLR ligands to induce the expression of pro-labour mediators; namely, proinflammatory cytokines and chemokines, contraction-associated proteins and prostaglandins, and extracellular matrix remodelling enzymes, matrix metalloproteinases. The data presented in this study suggest that Mincle is required when infl...Continue Reading

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Citations

Jul 7, 2020·Frontiers in Physiology·Justin G PadronClaire E Kendal-Wright
Nov 22, 2019·Clinical Science·Ratana LimMartha Lappas
Jul 24, 2020·International Journal of Molecular Sciences·Dimitri Leonid Lindenwald, Bernd Lepenies
Mar 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Depeng YangYu Li

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