Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina

Molecular Neurobiology
Ping ZhuQiuhong Li

Abstract

A local renin-angiotensin system (RAS) exists in the retina and plays a critical role in retinal neurovascular function. The protective axis of RAS comprising of angiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7) [Ang-(1-7)]/Mas receptor attenuate the deleterious actions of increased levels of angiotensin II (Ang II), the main effector peptide of RAS. A new peptide, alamandine, and its receptor Mas-related G protein-coupled receptor D (MrgD) have been recently identified that share structural and functional similarity to Ang-(1-7) and its receptor, Mas, establishing another new protective axis of RAS. Here, we examined the expression and cellular localization of MrgD in the retina, the effect of MrgD deficiency on mouse retinal structure and function, as well as the biological function of alamandine in cultured retinal cells. We showed that MrgD is expressed in the retinal neurons, retinal vasculature, Müller glial and RPE cells, similar to Mas receptor expression. MrgD-deficient mice did not exhibit gross change in retinal morphology and thickness; however, these mice did show a progressive decrease in both scotopic and photopic a-wave and b-wave amplitudes, and increase in retinal capillary loss with age compared to age...Continue Reading

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Citations

Feb 2, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Maria Cristina SavastanoUNKNOWN Gemelli Against COVID-19 Post-Acute Care Study Group
Mar 7, 2021·International Journal of Molecular Sciences·Barbara MalinowskaEberhard Schlicker
May 30, 2021·BMC Pharmacology & Toxicology·Ava Soltani HekmatKazem Javanmardi

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Methods Mentioned

BETA
genotyping
Fluorescence
dissection
Protein Assay
electrophoresis
PCR
Assay

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