Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis

Biochemical and Biophysical Research Communications
Mami UemuraYoshiakira Kanai

Abstract

In early-organogenesis-stage mouse embryos, the posteroventral foregut endoderm adjacent to the heart tube gives rise to liver, ventral pancreas and gallbladder. Hepatic and pancreatic primordia become specified in the posterior segment of the ventral foregut endoderm at early somite stages. The mechanisms for demarcating gallbladder and bile duct primordium, however, are poorly understood. Here, we demonstrate that the gallbladder and bile duct progenitors are specified in the paired lateral endoderm domains outside the heart field at almost the same timing as hepatic and pancreatic induction. In the anterior definitive endoderm, Sox17 reactivation occurs in a certain population within the most lateral domains posterolateral to the anterior intestinal portal (AIP) lip on both the left and right sides. During foregut formation, the paired Sox17-positive domains expand ventromedially to merge in the midline of the AIP lip and become localized between the liver and pancreatic primordia. In Sox17-null embryos, these lateral domains are missing, resulting in a complete loss of the gallbladder/bile-duct structure. Chimera analyses revealed that Sox17-null endoderm cells in the posteroventral foregut do not display any gallbladder/bi...Continue Reading

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Citations

Feb 5, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·A D Gracz, S T Magness
Sep 17, 2013·Genesis : the Journal of Genetics and Development·Silvia EngertHeiko Lickert
Feb 9, 2012·Mechanisms of Development·Donghun ShinDidier Y R Stainier
Mar 26, 2014·Molecular and Cellular Biology·Ikuo NobuhisaTetsuya Taga
Oct 26, 2018·Nature Communications·Xiaoqiu WangFrancesco J DeMayo
Nov 27, 2019·Cold Spring Harbor Perspectives in Biology·Silvia RuzittuFrancesca M Spagnoli
Feb 5, 2015·The Journal of Veterinary Medical Science·Mami UemuraYoshiakira Kanai
Jun 2, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Montri PattarapanawanYoshiakira Kanai
Dec 30, 2020·Xenotransplantation·Rajagopal N Aravalli
Aug 21, 2013·Biology Open·Yohei SaitoNaoki Takahashi

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