Expression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity.

Cellular and Molecular Life Sciences : CMLS
Alexandra Kollara, Theodore J Brown

Abstract

Nuclear receptor coactivator 4 (NcoA4), also known as androgen receptor-associated protein 70 (ARA70), was initially discovered as a component of Ret-Fused Gene expressed in a subset of papillary thyroid carcinomas. Subsequent studies have established NcoA4 as a coactivator for a variety of nuclear receptors, including peroxisome proliferator activated receptors α and γ, and receptors for steroid hormones, vitamins D and A, thyroid hormone, and aryl hydrocarbons. While human NcoA4 has both LXXLL and FXXLF motifs that mediate p160 coactivator nuclear receptor interactions, this ubiquitously expressed protein lacks clearly defined functional domains. Several studies indicate that NcoA4 localizes predominantly to the cytoplasm and affects ligand-binding specificity of the androgen receptor, which has important implications for androgen-independent prostate cancer. Two NcoA4 variants, which may exert differential activities, have been identified in humans. Recent studies suggest that NcoA4 may play a role in development, carcinogenesis, inflammation, erythrogenesis, and cell cycle progression that may be independent of its role as a receptor coactivator. This review summarizes what is currently known of the structure, expression, r...Continue Reading

References

Jan 1, 1994·European Journal of Applied Physiology and Occupational Physiology·K InoueE Sugimoto
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·S Yeh, C Chang
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·S YehC Chang
Jun 17, 1998·Molecular Endocrinology·E TreuterJ A Gustafsson
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·H MiyamotoC Chang
Jul 24, 1998·Biochemical and Biophysical Research Communications·S YehC Chang
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·H MiyamotoC Chang
Nov 24, 1999·Molecular and Cellular Biology·C L BevanM G Parker
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·S YehC Chang
Jun 1, 2001·Molecular Human Reproduction·J L Stanton, D P Green
Jun 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·H K LinC Chang
Nov 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M HembergerH Himmelbauer
Jan 10, 2002·The Journal of Biological Chemistry·Bin HeElizabeth M Wilson
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Huei-Ju TingChawnshang Chang
Jan 31, 2002·Molecular Endocrinology·Zhong-xun ZhouFrank S French
Jan 31, 2002·Molecular Human Reproduction·J L Stanton, D P L Green
Jul 19, 2002·International Journal of Cancer. Journal International Du Cancer·Angeliki MagklaraEleftherios P Diamandis
Oct 9, 2002·The American Journal of Pathology·Peng LiZhengxin Wang
Nov 25, 2003·Journal of Leukocyte Biology·Xueqing ZhangPeter E Newburger
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·John P RussellJay L Rothstein
Apr 22, 2004·The Journal of Biological Chemistry·Jamie M R MooreR Kiplin Guy

❮ Previous
Next ❯

Citations

Jan 5, 2016·Trends in Biochemical Sciences·Alexander R BogdanYoshiaki Tsuji
Oct 28, 2015·Molecular Human Reproduction·Julia Spencer BartholdAlan K Robbins
Oct 16, 2015·Molecular Neurobiology·Giorgio BiasiottoIsabella Zanella
Jan 15, 2019·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Heewon ParkSatoru Miyano
Oct 27, 2018·Pharmaceuticals·Naiara Santana-Codina, Joseph D Mancias
Apr 4, 2017·Médecine sciences : M/S·Ahmed Hamaï, Maryam Mehrpour
Nov 28, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Magdalena GryzikMaura Poli

❮ Previous
Next ❯

Methods Mentioned

BETA
two-hybrid
transgenic
confocal microscopy
pull-down
co-immunoprecipitation

Software Mentioned

Blastp
Ensembl Human Genome Browser

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biochemical and Biophysical Research Communications
Alexandra Kollara, Theodore J Brown
The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Alexandra Kollara, Theodore J Brown
Endocrine-related Cancer
Scott M Dehm, Donald J Tindall
© 2021 Meta ULC. All rights reserved