PMID: 8970998Dec 1, 1996Paper

Expression and function of the equine herpesvirus 1 virion-associated host shutoff homolog

Journal of Virology
X FengG B Caughman

Abstract

The ability of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2, respectively) to repress host cell protein synthesis early in infection has been studied extensively and found to involve the activities of the UL41 gene product, the virion-associated host shutoff (vhs) protein. To date, UL41 homologs have been identified in the genomes of three other alphaherpesviruses: equine herpesvirus 1 (EHV-1), varicella-zoster virus, and pseudorabies virus, but very little is known about the putative products of these homologous genes. Our earlier observations that no rapid early host protein shutoff occurred in EHV-1-infected cells led us to test EHV-1 vhs activity more thoroughly and to examine the expression and function of the EHV-1 UL41 homolog, ORF19. In the present study, the effects of EHV-1 and HSV-1 infections on cellular protein synthesis and mRNA degradation were compared at various multiplicities of infection in several cell types under an actinomycin D block. No virion-associated inhibition of cellular protein synthesis or vhs-induced cellular mRNA degradation was detected in cells infected with any of three EHV-1 strains (Ab4, KyA, and KyD) at multiplicities of infection at which HSV-1 strain F exhibited maximal vhs activ...Continue Reading

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Citations

May 8, 2010·The Journal of Veterinary Medical Science·Hui-Wen LinTien-Jye Chang
Jul 30, 2003·Journal of Virology·Geert Van MinnebruggenHans J Nauwynck
Jan 18, 2018·Virology Journal·Tianqiong HeXiaoyue Chen
May 26, 1997·Virology·N OsterriederJ D Baines

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