Expression and function of toll-like receptors in multiple myeloma patients: toll-like receptor ligands promote multiple myeloma cell growth and survival via activation of nuclear factor-kappaB

British Journal of Haematology
Yang XuDepei Wu

Abstract

Toll like receptors (TLRs) are the major agents for innate immunity that recognize invading microbial products and regulate the growth of normal and malignant human B lymphocytes. Multiple myeloma (MM) is a clonal plasma cell malignancy, though the regulatory role of TLRs in MM plasma cells has been reported, the molecular mechanism remains unclear. We first compared the transcripts of TLR1 to TLR10 in MM patients and healthy donors and found that TLR2, -4 and -9 transcripts were higher in bone marrow mononuclear cells (BMMCs) from patients than those from donors; in addition the expression of TLR4 and TLR9 were higher in MM cells than normal cells as demonstrated by flow cytometric analyses. The ligands of these two TLRs were capable to promote the growth of MM cells and protect them from serum-deprivation-induced apoptosis but not normal plasma cells, which could be attenuated with anti-IL6 neutralizing antibodies or blockage of NF-kappaB activities. Further investigation demonstrated that these TLR ligands could trigger the nuclear translocation of NF-kappaB p65 and the activated NF-kappaB was sufficient to increase the expression of IL6 transcript in MM cells. These data suggested that activated NF-kappaB signalling probabl...Continue Reading

References

Sep 1, 1992·Leukemia & Lymphoma·F Caligaris-CappioL Bergui
Dec 29, 2000·Nature·H HemmiS Akira
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Veit HornungGunther Hartmann
Nov 26, 2002·Hematology·Kenneth C AndersonG David Roodman
Jul 9, 2003·Immunological Reviews·Teru HideshimaKenneth C Anderson
Aug 2, 2003·The Journal of Biological Chemistry·Shizuo Akira
Sep 11, 2003·The Lancet Oncology·Sonja SeidlJohannes Drach
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroyuki NagaseKoichi Hirai
Feb 21, 2004·Science·Sandra S DieboldCaetano Reis e Sousa
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Sep 30, 2004·Nature Immunology·Akiko Iwasaki, Ruslan Medzhitov
Oct 29, 2004·The New England Journal of Medicine·Robert A Kyle, S Vincent Rajkumar
Dec 15, 2004·Microbes and Infection·Chandrashekhar Pasare, Ruslan Medzhitov
Feb 17, 2005·European Journal of Immunology·Maria ManukyanHolger Heine
Mar 4, 2005·Molecular and Cellular Biology·Souad RahmouniTomas Mustelin
Jan 18, 2006·Cell Death and Differentiation·T Kawai, S Akira
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Sep 5, 2007·Haematologica·Cindy GrandjenettePierre Feugier
Sep 28, 2007·British Journal of Haematology·Anne F McGettrick, Luke A J O'Neill
Mar 12, 2008·Blood·Robert A Kyle, S Vincent Rajkumar
Nov 28, 2008·British Journal of Haematology·Marta MuzioFederico Caligaris-Cappio

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Citations

Nov 21, 2013·Biomarker Research·Woodrow J CokerYubin Kang
Sep 21, 2013·Critical Reviews in Oncology/hematology·Sara HarsiniNima Rezaei
Aug 13, 2014·Journal of Hematology & Oncology·Johana M Isaza-CorreaLydia Visser
Jan 18, 2011·Critical Reviews in Oncology/hematology·Jahangir AbdiFrank Redegeld
Sep 8, 2016·Expert Opinion on Drug Discovery·Maria BatoolSangdun Choi
Oct 14, 2016·Frontiers in Immunology·Darlene A MonlishLaura G Schuettpelz
Jun 10, 2016·International Journal of Oncology·María Sánchez-CuaxospaCarmen Maldonado-Bernal
Dec 31, 2019·Cell Biochemistry and Function·Miloš DiklićVladan P Čokić
Nov 18, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Man NieWenqi Jiang

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