Expression and functional coupling of liver β2 - adrenoceptors in the human hepatocellular carcinoma

Pharmacology
Woubet T KassahunGetu Abraham

Abstract

Hepatocellular carcinoma (HCC) is one of the most common cancers and a leading cause of death worldwide. There are now multiple lines of evidence demonstrating that the β-adrenoceptor ( β-AR) signaling plays an important role in the progression and metastasis of cancer and may become a novel target for cancer therapy. Little information exists regarding the status of β-ARs and their postreceptor intracellular signaling cascade in the development of human HCC. This study was conducted to detect the expression signal transduction of the β-ARs in liver membranes obtained from patients with HCC and elucidate their possible implication on HCC development. The β-AR density and subtype distribution were determined by receptor binding studies. Protein levels of the β(2)-AR and G(s)(α) protein were determined by Western blot analysis. The receptor coupling efficiency and biochemical activities of the adenylate cyclase(AC) was also determined. In HCC liver membranes, the β(2)-AR density was higher than the density in the nonadjacent nontumor liver membranes. The β(2)-AR protein expression was 1.5-fold increased as compared with nonmalignant controls, and positively correlated with the receptor density. The G s protein expression as well ...Continue Reading

Citations

Jul 25, 2013·Advances in Therapy·Bjørn S MadsenAleksander Krag
Oct 31, 2013·Journal of Medicinal Chemistry·Luke J LemanM Reza Ghadiri
Jul 2, 2021·Frontiers in Physiology·Xiaoxu YangJingyu Xu

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