Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma

PloS One
Alexander H BenzFaramarz Dehghani

Abstract

Cannabinoid receptor 1 (CB1) is expressed in certain types of malignancies. An analysis of CB1 expression and function in Hodgkin lymphoma (HL), one of the most frequent lymphomas, was not performed to date. We examined the distribution of CB1 protein in primary cases of HL. Using lymphoma derived cell lines, the role of CB1 signaling on cell survival was investigated. A predominant expression of CB1 was found in Hodgkin-Reed-Sternberg cells in a vast majority of classical HL cases. The HL cell lines L428, L540 and KM-H2 showed strong CB1-abundance and displayed a dose-dependent decline of viability under CB1 inhibition with AM251. Further, application of AM251 led to decrease of constitutively active NFκB/p65, a crucial survival factor of HRS-cells, and was followed by elevation of apoptotic markers in HL cells. The present study identifies CB1 as a feature of HL, which might serve as a potential selective target in the treatment of Hodgkin lymphoma.

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Citations

Jan 17, 2016·Molecular and Cellular Endocrinology·Jana ErnstFaramarz Dehghani
Feb 9, 2016·European Journal of Pharmacology·Farideh A JavidAlessia Ligresti
Jun 15, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Guillermo VelascoMar Lorente
May 11, 2015·Cellular and Molecular Life Sciences : CMLS·Valeria GasperiMaria Valeria Catani
May 6, 2016·Cell Adhesion & Migration·Tim HohmannFaramarz Dehghani
May 19, 2017·British Journal of Pharmacology·David B FinlayMichelle Glass
Apr 18, 2018·British Journal of Pharmacology·Ana Isabel Fraguas-SánchezAna Isabel Torres-Suárez
Jun 20, 2019·Frontiers in Pharmacology·Paula Morales, Nadine Jagerovic
Dec 29, 2016·Oncotarget·Maria ManginiStefania Mariggiò
Aug 1, 2018·Laryngoscope Investigative Otolaryngology·Lucas M BryantJoseph M Curry
Nov 5, 2020·Cancers·Emily S SeltzerDong Zhang
Dec 2, 2020·International Journal of Molecular Sciences·Melanie KienzlRudolf Schicho
Jan 11, 2021·Advances in Biological Regulation·Pratibha MalhotraMarco Falasca
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natasha IrreraAlessandro Allegra

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Methods Mentioned

BETA
PCR
Assay

Software Mentioned

GraphPad
GraphPad Prism
DIVA
QuantiScan

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