Expression and functional role of hepatocyte growth factor receptor (C-MET) during postnatal rat testis development

Endocrinology
A CatizoneM Galdieri

Abstract

The met protooncogene encodes the hepatocyte growth factor receptor (HGFR, c-met). C-met, a tyrosine kinase receptor protein, is widely expressed in different cell types including the male reproductive tract. As we recently demonstrated, both c-met messenger RNA and protein are expressed in prebuberal rat testis. The aim of this work was to detect the expression of c-met during postnatal testis development and to study its functional role. Our findings show that in total rat testis c-met is expressed during postnatal life until the sexual maturation of the animals. To evaluate the receptor expression in the different cell types in the testis, homogeneous cell populations of Sertoli and peritubular myoid cells were isolated from the seminiferous tubules of 10- and 35-day-old animals. c-met gene is expressed in myoid cells at the ages considered and its expression decreases with increasing age. By contrast, in Sertoli cells c-met expression is first detectable at 25 days of life and its expression increases with the increasing age being well evident at 35 days of age. C-met protein was detected by immunocytochemistry and its expression correlates with gene expression. The receptor is functionally active because HGF administration...Continue Reading

References

Dec 1, 1979·Cell Differentiation·J C DavidJ Signoret
Aug 1, 1990·Developmental Biology·M A HadleyM Dym
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M ParkG Vande Woude
Aug 16, 1984·Biochemical and Biophysical Research Communications·T NakamuraA Ichihara
Aug 1, 1995·Experimental Cell Research·C D MoorbyE Gherardi
Sep 14, 1995·Biochemical and Biophysical Research Communications·K IkejimaN Sato
Jun 1, 1995·The Journal of Cell Biology·R Zarnegar, G K Michalopoulos
Mar 1, 1993·American Journal of Respiratory Cell and Molecular Biology·K M WeidnerW Birchmeier
Jun 14, 1996·The Journal of Biological Chemistry·C PonzettoP Comoglio
Apr 1, 1996·Journal of Biochemistry·K Matsumoto, T Nakamura
Oct 8, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L TrusolinoP M Comoglio
Jun 29, 1999·Endocrinology·A CatizoneM Galdieri

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Citations

Oct 21, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ashley C WozniakJudy E Anderson
Dec 27, 2016·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert E ChapinJan-Bernd Stukenborg
Feb 12, 2008·Journal of Cellular Physiology·A CatizoneM Galdieri
Jul 13, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Tony Manibur RahmanHumphrey Hodgson
Mar 1, 2006·Reproductive Medicine and Biology·Masato Fujisawa

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