Expression and glucocorticoid regulation of natriuretic peptide clearance receptor (NPR-C) mRNA in rat brain and choroid plexus

Journal of Chemical Neuroanatomy
J P HermanM C Langub

Abstract

The natriuretic peptide clearance receptor (NPR-C) binds atrial natriuretic peptide, brain natriuretic peptide and C-type natriuretic peptide with high affinity. This receptor lacks an intracellular guanylate cyclase domain, and is believed to exert biological actions by sequestration of released natriuretic peptides and/or inhibition of adenylate cyclase. The present report summarizes the first detailed mapping of NPR-C mRNA in rat brain. In situ hybridization analysis revealed high levels of NPR-C mRNA expression in frontal and retrosplenial granular cortices, medial preoptic nucleus, ventral cochlear nucleus and choroid plexus. NPR-C mRNA expression was also observed in deep layers of neocortex and limbic cortex, posterior cortical amygdala, ventral subiculum, amygdalohippocampal area, and dentate gyrus. Positive hybridization signal was observed in both anterior and intermediate lobes of the pituitary gland. Regulatory studies indicated that expression of NPR-C mRNA was increased in the medial preoptic nucleus of adrenalectomized rats, suggesting negative glucocorticoid regulation. No changes in NPR-C mRNA expression were observed in frontal cortex or choroid plexus. These results suggest a role for the NPR-C in modulation ...Continue Reading

References

Oct 1, 1991·Canadian Journal of Physiology and Pharmacology·J M Saavedra, M Kurihara
Nov 15, 1986·The Journal of Comparative Neurology·D G StandaertC B Saper
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
May 29, 1995·The Journal of Comparative Neurology·M C LangubJ P Herman
Jan 1, 1995·Clinical and Experimental Pharmacology & Physiology·Y OgawaK Nakao
Aug 1, 1993·Cellular and Molecular Neurobiology·J P Herman
Jul 1, 1993·The American Journal of Physiology·W TangC Sumners
May 27, 1996·The Journal of Comparative Neurology·J P HermanM C Langub

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Citations

Feb 15, 2001·Critical Care : the Official Journal of the Critical Care Forum·K IkedaT Fukuda
Dec 17, 2003·Kidney International·Stephen L CarrithersRichard N Greenberg
Sep 29, 2011·Neuropharmacology·Q WangP J Lucassen
Jan 25, 2008·Progress in Neurobiology·Li-Hui Cao, Xiong-Li Yang
Mar 9, 2018·The Journal of Experimental Biology·Katharina BraunMartin Klingenspor
Jan 26, 2018·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Huang Huang LuoBo Hu
Jun 2, 2016·Journal of the American Heart Association·Colleen M DeweyChad E Grueter
Jan 3, 2001·Microscopy Research and Technique·A Chodobski, J Szmydynger-Chodobska
Dec 14, 2004·Journal of the American Society of Nephrology : JASN·Songcang ChenDavid G Gardner
May 14, 2014·Nature Reviews. Cardiology·Nora E ZoisJens P Goetze

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