Expression and glycosylation of MUC1 in epidermolysis bullosa-associated and sporadic cutaneous squamous cell carcinomas

The British Journal of Dermatology
H L CooperE Healy

Abstract

Cutaneous squamous cell carcinoma (SCC) is particularly problematic in certain patient groups, including patients with dystrophic or junctional epidermolysis bullosa (DEB/JEB). Theoretically, vaccination against a cell surface antigen which is expressed on this type of tumour could prevent SCC development, as well as treat primary and metastatic disease in this patient group. Preliminary studies have suggested that MUC1, a transmembrane glycoprotein, is overexpressed in sporadic cutaneous SCCs, and MUC1 has been used with some success as a target antigen for vaccine development in breast cancer, where it is expressed on > 50% of neoplastic cells in approximately 50-80% of tumours. Furthermore, aberrant glycosylation of MUC1 has been detected in this and other cancer types; however, the glycosylation status of MUC1 in cutaneous SCC is not known. To investigate the expression and glycosylation status of MUC1 in SCCs arising in patients with DEB and JEB, and for comparison in sporadic SCCs and sporadic Bowen's disease. Immunohistochemical analysis of MUC1 in 30 SCCs from subjects with DEB/JEB, 55 sporadic SCCs and 30 sporadic lesions of Bowen's disease was carried out using four separate monoclonal antibodies which recognize diffe...Continue Reading

References

Apr 1, 1992·Journal of Cutaneous Pathology·J A McGrathR A Eady
Jul 13, 1991·Lancet·B LindelöfL Molin
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y T ChenL J Old
May 29, 1997·International Journal of Cancer. Journal International Du Cancer·A BaruchD H Wreschner
Aug 12, 1998·International Journal of Cancer. Journal International Du Cancer·C A ReisM Sobrinho-Simões
May 26, 1999·Pharmacology & Therapeutics·D W Miles, J Taylor-Papadimitriou
Sep 30, 1999·International Journal of Cancer. Journal International Du Cancer·E C MommersP J van Diest
Nov 26, 1999·Biochimica Et Biophysica Acta·J Taylor-PapadimitriouM Dalziel
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P MukherjeeS J Gendler
May 29, 2001·Journal of Clinical Pathology·R L ten BergeC J Meijer
Dec 11, 2002·Clinical and Experimental Dermatology·R Mallipeddi

❮ Previous
Next ❯

Citations

Dec 18, 2007·Journal of Cellular and Molecular Medicine·R F SmithA A Smith
Mar 16, 2013·Journal of Cutaneous Pathology·Yumi HondaKen-ichi Iyama
May 8, 2014·BioResearch Open Access·Priyadarsini KumarGordon C Douglas
Jul 28, 2019·Journal of Immunoassay & Immunochemistry·Asmaa Gaber AbdouMarwa Ali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bowen's Disease

Bowen's disease is thought of as an easily-treatable early stage of skin cancer, characterized by red, scaly patches on the skin. Discover the latest research on Bowen's disease here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.