PMID: 11342960May 9, 2001Paper

Expression and immunogenicity of oncofetal antigen-immature laminin receptor in human renal cell carcinoma

The Journal of Urology
C Zelle-RieserM Thurnher

Abstract

The 32 to 44 kDa. oncofetal antigen-immature laminin receptor (OFA-iLR) is a multifunctional protein expressed by various tumors, including breast, lung, ovary and prostate carcinoma as well as lymphoma. OFA-iLR has been implicated in tumor invasiveness, metastasis and growth. Interferon-gamma producing effector T cells and interleukin (IL)-10 producing suppressor T cells specific for OFA-iLR have been described. The 43515 IgG2a anti-OFA-iLR monoclonal antibody was used to detect OFA-iLR expression in human renal cell carcinoma tissue by flow cytometry and immunoblotting. Spontaneous or therapy induced immune responses against OFA-iLR were determined in patients with metastatic renal cell carcinoma. Proliferative and cytokine (interferon-gamma and IL-10) responses of peripheral blood mononuclear cells from patients with renal cell carcinoma against recombinant OFA-iLR were assessed. Using flow cytometry OFA-iLR was detected in all 13 tumors tested. Immunoblotting revealed differences in OFA-iLR expression in renal cell carcinoma and normal kidney tissue. OFA-iLR specific proliferative and cytokine responses of mononuclear cells were detected in all 6 patients tested. Importantly evidence was also obtained that treating metastat...Continue Reading

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Citations

Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jon J van RoodCladd E Stevens
Oct 27, 2004·Expert Opinion on Biological Therapy·Johannes Vieweg, Andrew Jackson
Sep 12, 2006·Urologic Oncology·Johannes Vieweg
Sep 19, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·P Nguyen van Binh, H T Duc
Mar 17, 2007·The Journal of Comparative Neurology·Woochan JangJames E Schwob
Apr 22, 2008·Cellular & Molecular Biology Letters·Tharinee Susantad, Duncan R Smith
Aug 2, 2014·Cellular & Molecular Biology Letters·Adel L Barsoum, Paul O Schwarzenberger

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