PMID: 12753360May 20, 2003Paper

Expression and intracellular localization of progesterone receptors in cultured human gingival fibroblasts

Journal of Periodontal Research
Kazuko Kawahara, Atsushi Shimazu

Abstract

The aim of this immunocytochemical study was to characterize the expression and distribution of the progesterone receptor (PR) and estrogen receptor (ER) in gingival fibroblasts using culture cells derived from people at various ages. The reaction of female hormones is tissue or cell specific, and receptor availability in the cell is one of the major causes for the different reactions. Gingiva is a target tissue for female hormones; however, the characteristics of PR and ER in both the fibroblasts and the other component cells remain largely unknown. Gingival tissue was obtained from six people at various ages and culture fibroblasts were established. At least three passages of each cell line were strained for PR and ER with monoclonal antibodies (Clone 1A6, Clone 1D5, respectively). PR positive cells were detected in all six cell lines through early passages to late ones, but ER were only observed in two of six samples with faint reactions. The staining intensity for PR was greater than for ER, but less than that shown in the MCF-7 breast cancer cells, positive control. In every positive control test, ER reactivity was equal to or higher than that of PR. During the interphase, significantly fewer positive fibroblasts occurred ...Continue Reading

References

Dec 1, 1978·The Journal of Clinical Endocrinology and Metabolism·A L SouthrenJ Vittek
May 1, 1992·Oral Surgery, Oral Medicine, and Oral Pathology·A ForaboscoA Volpe
Jan 1, 1992·Archives of Oral Biology·A Ojanotko-HarriP Tuohimaa
Dec 1, 1991·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S CassanelliD Seigneurin
May 1, 1990·The Journal of Prosthetic Dentistry·W F CaughmanG S Schuster
Jun 15, 1990·Cancer Letters·C LanariE H Charreau
Jan 1, 1985·Journal of Periodontal Research·J VittekA L Southren
Nov 1, 1986·The Journal of Investigative Dermatology·J P BentleyN MacDonald
Mar 1, 1982·The Journal of Clinical Endocrinology and Metabolism·J VittekA L Southren
Dec 1, 1994·Oral Surgery, Oral Medicine, and Oral Pathology·S B WhitakerT J Whitaker
Oct 1, 1994·The Journal of Pediatric Endocrinology·A O Brinkmann
Oct 21, 1999·Biology of Reproduction·G A JohnsonT E Spencer
Apr 25, 2000·Journal of Periodontology·W Y YihM B Zieper
Sep 28, 2000·Maturitas·R Leimola-VirtanenS Syrjänen

❮ Previous
Next ❯

Citations

Mar 12, 2010·Journal of Periodontology·Sema BecerikGülnur Emingil
Jul 15, 2015·Biomedical Reports·Sakiko FujiiYukio Kato
Sep 23, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Talieh KazerooniYasaman Kazerooni
Oct 24, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Michele Conceição PereiraJacks Jorge
Dec 18, 2012·Periodontology 2000·Angelo Mariotti, Michael Mawhinney
Dec 19, 2014·Clinical Oral Investigations·Carlos Heitor Cunha MoreiraCassiano Kuchenbecker Rösing
Apr 16, 2015·Mediators of Inflammation·Min WuShao-Yun Jiang
Aug 21, 2020·Geburtshilfe und Frauenheilkunde·Anna-Maria Kühle, Jürgen Wacker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.