Expression and localisation of kinin receptors in colorectal polyps

International Immunopharmacology
W ZelawskiAntoni Stadnicki

Abstract

Kinins increase vascular permeability as well as mitogenesis and proliferation, hence they have a potential to promote neoplasmatic transformation. In the present study we investigated the expression profile and localization of kinin B1 and B2 receptors in colorectal polyps. The biopsy samples from various polyps were obtained during endoscopy in tubular (n=18), villous (n=15) and hyperplasic polyps (n=15). The expression of genes encoding B1 and B2 was estimated by QRT-PCR TaqMan analysis. In second series B1 and B2 receptors were visualized by immunohistochemical staining in tissue specimens from colonic polyps and adjacent normal tissue. We found the highest expression of gene encoding B1 in tubular adenomas (1891 number of copies mRNA/microg total RNA+/-312 SE) which is significantly higher as compared with controls (683+/-197 SE, p<0.013). In contrast, the expression of gene for B2 was significantly increased in hyperplastic polyps (3852+/-936 SE) as compared with controls (843+/-263 SE, p<0.0016). In normal colon a well as in hyperplasic polyps B1 and B2 receptors were immunohistochemically localized in enterocytes, however in hyperplastic polyps the intensity of staining was more prominent for B2 comparing to the control...Continue Reading

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Citations

Mar 17, 2011·Digestive Diseases and Sciences·Priyanka KachrooRobert S Chapkin
Feb 22, 2012·Expert Opinion on Therapeutic Targets·Carlos D FigueroaKanti D Bhoola
Dec 18, 2013·Cancer Letters·Patrícia L N da CostaRoger Chammas
Sep 18, 2010·Inflammatory Bowel Diseases·Antoni Stadnicki
Apr 6, 2018·BMC Cancer·Patricia Luiza Nunes da CostaChristopher Christophi
Feb 26, 2016·World Journal of Gastrointestinal Pathophysiology·Mei-Hua QuZhi-Qin Gao
Nov 24, 2017·Expert Opinion on Therapeutic Targets·Fatimunnisa Qadri, Michael Bader
Jan 29, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Meir WarmanOded Cohen
Mar 7, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kuo-Shyan LinFrançois Bénard

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