Expression and localization of BCRP, MRP1 and MRP2 in intestines, liver and kidney in horse

Journal of Veterinary Pharmacology and Therapeutics
E TydénP Larsson

Abstract

The gene and protein expression and the cellular localization of the ABC transport proteins breast cancer resistance protein (BCRP), multidrug resistance-associated protein 1 (MRP1) and multidrug resistance-associated protein 2 (MRP2) have been examined in the intestines, liver and kidney in horse. High gene and protein expression of BCRP and MRP2 were found in the small intestines, with cellular localization in the apical membranes of the enterocytes. In the liver, MRP2 was present in the bile canalicular membranes of the hepatocytes, whereas BCRP was localized in the cytoplasm of hepatocytes in the peripheral parts of the liver lobuli. In the kidney both BCRP and MRP2 were predominantly present in the distal tubuli and in the loops of Henle. In most tissues, the gene and protein expression of MRP1 were much lower than for BCRP and MRP2. Immunostaining of MRP1 was detectable only in the intestines and with localization in the cytoplasm of enterocytes in the caecum and colon and in the cells of serous acini of Brunner's glands in the duodenum and the upper jejunum. The latter cells were also stained for BCRP, but not for MRP2. Many drugs used in horse are substrates for one or more of the ABC transport proteins. These transport...Continue Reading

References

Apr 9, 1998·International Journal of Cancer. Journal International Du Cancer·M J Van LuynE G De Vries
May 20, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K C PengA Vandewalle
Sep 16, 2000·European Journal of Pharmacology·R A Van AubelF G Russel
Jan 22, 2003·Advanced Drug Delivery Reviews·Alfred H Schinkel, Johan W Jonker
Apr 2, 2003·Journal of Veterinary Pharmacology and Therapeutics·K TörnekeH Broström
Apr 10, 2004·Drug Metabolism Reviews·Shufeng ZhouBalram Chowbay
Feb 3, 2005·International Journal of Cancer. Journal International Du Cancer·Jörg KönigDietrich Keppler
Feb 18, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Cindy Q XiaLiang-Shang Gan
Jul 2, 2005·Cancer Letters·Patricia A FetschSusan E Bates
Dec 31, 2005·Chemico-biological Interactions·Anne LespineMichel Alvinerie
Jan 18, 2006·Drug Metabolism and Pharmacokinetics·Masuhiro Nishimura, Shinsaku Naito
Sep 9, 2006·Journal of Veterinary Pharmacology and Therapeutics·J L DavisM G Papich
Dec 1, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Anne LespineMichel Alvinerie
Mar 14, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Junichi EnokizonoYuichi Sugiyama
May 3, 2007·Journal of Veterinary Pharmacology and Therapeutics·L OlsénP Larsson
May 15, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Constanze HilgendorfJohan Karlsson
Mar 15, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yukio KatoAkira Tsuji
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Sep 16, 2008·The Journal of Pharmacology and Experimental Therapeutics·Miriam HulsRosalinde Masereeuw
Mar 18, 2009·Journal of Veterinary Pharmacology and Therapeutics·E TydénP Larsson

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Citations

Jun 8, 2011·Journal of Veterinary Pharmacology and Therapeutics·K L Mealey
Jun 4, 2011·Journal of Veterinary Pharmacology and Therapeutics·I A WasfiK M Al Neaimi
Aug 18, 2012·Journal of Veterinary Pharmacology and Therapeutics·V ZancanellaM Dacasto

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