Expression and localization of forkhead box protein FOXJ1 in S100β-positive multiciliated cells of the rat pituitary

Medical Molecular Morphology
Takashi NakakuraHaruo Hagiwara


S100β-positive cells exist in the marginal cell layer (MCL) of the adenohypophysis and follicle structure in the parenchyma of anterior lobe (ALFS) in pituitary. They have multiple functions as phagocytes or cells that regulate hormone secretion. Majority of S100β-positive cells in the adenohypophysis express sex determining region Y-box 2 protein (SOX2), a stem cell marker; therefore, S100β/SOX2 double positive cells are also considered as one type of stem/progenitor cells. MCL and ALFS are consisting of morphologically two types of cells, i.e., multiciliated cells and non-ciliated cells. However, the relationship between the S100β-positive cells and multiciliated cells in the pituitary is largely unknown. In the present study, we first immunohistochemically verified the feature of multiciliated cells in MCL and ALFS. We then examined the expression patterns of FOXJ1, an essential expression factor for multiciliated cell-differentiation, and SOX2 in the S100β-positive multiciliated cells by in situ hybridization and immunohistochemistry. We identified anew the S100β/SOX2/FOXJ1 triple positive multiciliated cells, and revealed that they were dispersed throughout the MCL and ALFS. These results indicate that the MCL and ALFS are...Continue Reading


Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·H HöflerG F Walter
Jan 1, 1980·Cell and Tissue Research·D R Ciocca
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·L LimR H Costa
May 20, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J W TichelaarJeffrey A Whitsett
Jul 29, 1999·American Journal of Respiratory Cell and Molecular Biology·E N BlattSteven L Brody
Jun 29, 2000·American Journal of Respiratory Cell and Molecular Biology·Steven L BrodyS D Shapiro
Jul 5, 2005·European Journal of Endocrinology·Wilfried Allaerts, Hugo Vankelecom
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Teddy FauquierIain C A F Robinson
Aug 30, 2008·Histochemistry and Cell Biology·Takashi NakakuraShigeyasu Tanaka
Nov 18, 2008·Nature Genetics·Jennifer L StubbsChris Kintner
Mar 11, 2009·Nature Reviews. Genetics·Sridhar Hannenhalli, Klaus H Kaestner
Feb 11, 2010·Journal of Cell Science·Robert A Bloodgood
Jul 21, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Takashi NakakuraShigeyasu Tanaka
Sep 22, 2010·American Journal of Respiratory Cell and Molecular Biology·David H TompkinsJeffrey A Whitsett
Jan 28, 2012·Acta Histochemica Et Cytochemica·Toshiyuki MatsuzakiHitoshi Ozawa
Jun 26, 2013·Nature Reviews. Cancer·Eric W-F LamChuay-Yeng Koo
Jul 5, 2013·Respiratory Research·Lukas DidonRonald G Crystal
Mar 20, 2014·Development·Semil P ChoksiSudipto Roy
Dec 25, 2015·Medical Molecular Morphology·Takashi NakakuraHaruo Hagiwara
Jan 14, 2016·International Journal of Molecular Sciences·Saishu YoshidaYukio Kato

Related Concepts

FOXJ1 protein, rat
Sox2 protein, rat
Cell Differentiation Process
Pituitary Gland, Anterior
Colony-forming Unit
Gene Expression
Rats, Wistar

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