Expression and localization of Muc4/sialomucin complex (SMC) in the adult and developing rat intestine: implications for Muc4/SMC function

Journal of Cellular Physiology
Min RongKermit L Carraway

Abstract

Muc4/sialomucin complex (SMC) is a high molecular mass heterodimeric membrane mucin, encoded by a single gene, and originally discovered in a highly metastatic ascites rat mammary adenocarcinoma. Subsequent studies have shown that it is a prominent component of many accessible and vulnerable epithelia, including the gastrointestinal tract. Immunoblot and immunofluorescence analyses demonstrated that Muc4/SMC expression in the rat small intestine increases from proximal to distal regions and is located predominantly in cells at the base of the crypts. These cells were postulated to be Paneth cells, based on their location, morphology, and secretory granule content. Immunohistochemistry indicated the presence of Muc4/SMC in these granules. Muc4/SMC expression was higher in the rat colon than small intestine and was abundantly present in colonic goblet cells, but not in goblet cells in the small intestine. Immunohistochemistry also suggested the presence of MUC4 in human colonic goblet cells. Biochemical analyses indicated that rat colonic Muc4/SMC is primarily the soluble form of the membrane mucin. Analyses of Muc4/SMC during development of the rat gastrointestinal tract showed its appearance at embryonic day 14 of the esophagus...Continue Reading

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Citations

Aug 3, 2010·The British Journal of Nutrition·Carlos A MontoyaJean-Paul Lallès
Mar 13, 2013·Nature Reviews. Gastroenterology & Hepatology·Malin E V JohanssonGunnar C Hansson
Jul 7, 2012·PloS One·Marisol ChangGeert W Schmid-Schönbein
Feb 18, 2016·Journal of Molecular Biology·Liisa Arike, Gunnar C Hansson
Aug 1, 2008·Expert Opinion on Medical Diagnostics·Subhankar ChakrabortySurinder K Batra
Jan 23, 2016·Digestive Diseases and Sciences·Sana RokhsefatElena M Comelli
Mar 21, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Yuichi KawaiNaoki Arizono
Apr 23, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Maria van der SluisIngrid B Renes
Apr 6, 2020·Food Research International·Mounira KebouchiMagali Genay

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