Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland

Advances in Experimental Medicine and Biology
L BernardYves Chilliard

Abstract

The effect of nutrition on milk fat yield and composition has largely been investigated in cows and goats, with some differences for fatty acid (FA) composition responses and marked species differences in milk fat yield response. Recently, the characterization of lipogenic genes in ruminant species allowed in vivo studies focused on the effect of nutrition on mammary expression of these genes, in cows (mainly fed milk fat-depressing diets) and goats (fed lipid-supplemented diets). These few studies demonstrated some similarities in the regulation of gene expression between the two species, although the responses were not always in agreement with milk FA secretion responses. A central role for trans-10 C18:1 and trans-10, cis-12 CLA as regulators of milk fat synthesis has been proposed. However, trans-10 C18:1 does not directly control milk fat synthesis in cows, despite the fact that it largely responds to dietary factors, with its concentration being negatively correlated with milk fat yield response in cows and, to a lesser extent, in goats. Milk trans-10, cis-12 CLA is often correlated with milk fat depression in cows but not in goats and, when postruminally infused, acts as an inhibitor of the expression of key lipogenic ge...Continue Reading

Citations

Nov 19, 2011·The British Journal of Nutrition·Beate HillerKarin Nuernberg
Mar 26, 2010·The Journal of Dairy Research·Roberto MantovaniGianfranco Gabai
Dec 19, 2012·The Journal of Dairy Research·Laurence BernardYves Chilliard
Jan 1, 2009·Animal : an International Journal of Animal Bioscience·K J HarvatineD E Bauman
Jul 1, 2010·Animal : an International Journal of Animal Bioscience·K J ShingfieldY Chilliard
Jul 1, 2010·Animal : an International Journal of Animal Bioscience·M BonnetB Picard
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·N MachM A Smits
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Aug 2, 2008·BMC Genomics·Massimo Bionaz, Juan J Loor
Mar 19, 2014·Animal : an International Journal of Animal Bioscience·D FernandesD E De Oliveira
Jan 7, 2016·Annual Review of Food Science and Technology·Jun Ho KimYeonhwa Park
Dec 17, 2014·Animal : an International Journal of Animal Bioscience·S ŚwiątkiewiczD Józefiak
Nov 11, 2017·Animal : an International Journal of Animal Bioscience·Y FaulconnierC Leroux

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