Expression and phosphorylation of Stathmin 1 indicate poor survival in head and neck squamous cell carcinoma and associate with immune suppression

Biomarkers in Medicine
Hao WuZhi-Jun Sun

Abstract

Immunohistochemistry was used to detect the expression of Stathmin 1 and Serine 38 phospho-Stathmin 1 (p-Stathmin 1S38) in head and neck squamous cell carcinoma (HNSCC) and research its correlation with clinical parameters, survival and expression of immune checkpoint molecules. Stathmin 1 and p-Stathmin 1S38 overexpression in primary HNSCC is associated with poor overall survival. Stathmin 1 expression is related to tumor size, category and lymph node status. Stathmin 1 expression correlates with PD-L1, TIM3, VISTA, B7-H3, B7-H4, LAG-3 and p-STAT3 expression in HNSCC. P-Stathmin 1S38 expression correlates with PD-L1, VISTA, B7-H4, LAG-3 and p-STAT3 in HNSCC. We found expression of Stathmin 1 and p-Stathmin 1S38 indicates poor survival in HNSCC and may be associated with immune suppression.

References

Dec 16, 1997·International Journal of Cancer. Journal International Du Cancer·A A AlaiyaG Auer
Jan 17, 2002·Current Opinion in Cell Biology·Lynne Cassimeris
Sep 24, 2004·Cancer Genetics and Cytogenetics·Gokce A TorunerJames J Dermody
Aug 18, 2005·British Journal of Cancer·L M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
May 20, 2008·Lancet·Athanassios ArgirisRobert L Ferris
Sep 2, 2008·Expert Review of Anticancer Therapy·Shushan RanaJohn Nemunaitis
Mar 3, 2009·The Journal of Biological Chemistry·Navin K VermaYuri Volkov
Apr 11, 2009·The Journal of Biological Chemistry·Tapas MannaLeslie Wilson
Dec 17, 2010·Nature Reviews. Cancer·C René LeemansRuud H Brakenhoff
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Apr 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erin L FilbertAndrey S Shaw
Jun 13, 2012·Expert Opinion on Therapeutic Targets·John Nemunaitis
Mar 30, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elisabeth WikHelga B Salvesen
Jul 29, 2015·CA: a Cancer Journal for Clinicians·Angela C ChiBrad W Neville
Jul 8, 2016·Cancer Immunology, Immunotherapy : CII·Lei WuZhi-Jun Sun
Sep 4, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Hai-Long MaZhi-Yuan Zhang
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 12, 2017·Future Oncology·Jia-Shun WuYa-Ling Tang
May 6, 2017·Nature Communications·Edward J MorrisShoukat Dedhar
Aug 16, 2017·Journal of Experimental & Clinical Cancer Research : CR·Hai-Long MaLai-Ping Zhong
Nov 16, 2017·OncoTargets and Therapy·Xiao-Lei GaoXin-Hua Liang

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Citations

Apr 11, 2019·The International Journal of Biological Markers·Dan ZhangYin LanNing
May 24, 2019·World Journal of Clinical Cases·Lin-Lin SuXiao-Ying Xue
Jul 10, 2020·Cell·Mehdi BouhaddouNevan J Krogan
May 27, 2021·PLoS Computational Biology·Halil İbrahim KuruOznur Tastan

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GraphPad Prism
MARKer
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