Expression and physiological role of three Myxococcus xanthus copper-dependent P1B-type ATPases during bacterial growth and development.

Applied and Environmental Microbiology
Aurelio Moraleda-MuñozJ Munoz-Dorado

Abstract

Myxococcus xanthus is a soil-dwelling bacterium that exhibits a complex life cycle comprising social behavior, morphogenesis, and differentiation. In order to successfully complete this life cycle, cells have to cope with changes in their environment, among which the presence of copper is remarkable. Copper is an essential transition metal for life, but an excess of copper provokes cellular damage by oxidative stress. This dual effect forces the cells to maintain a tight homeostasis. M. xanthus encodes a large number of genes with similarities to others reported previously to be involved in copper homeostasis, most of which are redundant. We have identified three genes that encode copper-translocating P(1B)-ATPases (designated copA, copB, and copC) that exhibit the sequence motifs and modular organizations of those that extrude Cu(+). The expression of the ATPase copC has not been detected, but copA and copB are differentially regulated by the addition of external copper. However, while copB expression peaks at 2 h, copA is expressed at higher levels, and the maximum is reached much later. The fact that these expression profiles are nearly identical to those exhibited by the multicopper oxidases cuoA and cuoB suggests that the ...Continue Reading

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Citations

Jun 22, 2010·Applied and Environmental Microbiology·Aurelio Moraleda-MuñozJosé Muñoz-Dorado
Jan 31, 2012·Applied and Environmental Microbiology·Nuria Gómez-SantosJosé Muñoz-Dorado
May 29, 2012·Journal of Bacteriology·Lici A Schurig-Briccio, Robert B Gennis
Jun 10, 2011·PLoS Genetics·Nuria Gómez-SantosJosé Muñoz-Dorado
Mar 10, 2016·Nucleic Acids Research·Francisco Javier Marcos-TorresJosé Muñoz-Dorado
Jul 3, 2018·Metallomics : Integrated Biometal Science·Juana PérezAurelio Moraleda-Muñoz
Mar 2, 2016·Environmental Microbiology Reports·María Celestina Sánchez-SutilJosé Muñoz-Dorado
Mar 3, 2020·Frontiers in Microbiology·Francisco Javier Contreras-MorenoAurelio Moraleda-Muñoz
Jun 13, 2019·Molecular Microbiology·Aurelio Moraleda-MuñozJosé Muñoz-Dorado
Aug 4, 2021·Annual Review of Microbiology·Yuan Ping LiChristopher Rensing

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