Expression and possible mechanism of c-ski, a novel tissue repair-related gene during normal and radiation-impaired wound healing

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Xia LiuYuan-Guo Zhou

Abstract

C-ski is a complicated regulating factor for fibroblast proliferation and an important co-repressor of Smad3. Although inhibiting Smad3 activity can markedly promote wound healing because Smad3 mediates the role of transforming growth factor-beta in inhibiting cell proliferation and inducing cell apoptosis; there has been no report on whether c-ski is expressed during wound healing and the relationship between its expression and wound healing. By establishing animal models of normal and radiation-impaired wound healing and using immunohistochemistry, in situ hybridization, and reverse transcription-polymerase chain reaction, we found that c-ski was expressed after wounding and reached its peak on day 9 and then significantly decreased. C-ski was present in all repair cells, and was especially prominent in fibroblasts. Compared with the control side, the irradiated side showed a lower expression of c-ski on postwound days 3-9, but higher on day 15, and not significantly different after the wound was healed. The expression of Smad3 was in contrast to the c-ski and cellular proliferation was similar to that of c-ski expression. The apoptosis index was significantly higher on the irradiated side on days 3-9 compared with the contro...Continue Reading

References

Jul 25, 1989·Nucleic Acids Research·N NomuraR Ishizaki
Dec 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·G E LyonsE Stavnezer
Apr 12, 1996·The Journal of Biological Chemistry·P J CzernikB K Hurlburt
Oct 24, 1998·The International Journal of Biochemistry & Cell Biology·D G Greenhalgh
Mar 10, 2000·Cytokine & Growth Factor Reviews·G S Ashcroft, A B Roberts
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·W XuE E Medrano
Jul 6, 2000·Advances in Immunology·K MiyazonoC H Heldin
Mar 21, 2001·Human Molecular Genetics·J R Nevins
Jun 22, 2002·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Chiho KanamaruToshiro Fujita
Oct 4, 2002·Journal of Wound Care·S O'Kane
Nov 12, 2002·The Journal of Biological Chemistry·Masafumi MizuideKohei Miyazono
Nov 21, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Arun Mehra, Jeffrey L Wrana
Dec 11, 2002·Current Opinion in Cell Biology·Olivier Stevaux, Nicholas J Dyson
Jan 18, 2003·Experimental Cell Research·Rachel Anna EvansAled Owain Phillips
Feb 8, 2003·Journal of Wound Care·C J Sylvia
Apr 5, 2003·American Journal of Physiology. Cell Physiology·K J KellyPierre C Dagher
Dec 12, 2003·Drugs of Today·Anna T Grazul-BilskaKay M Abdullah
Jan 9, 2004·International Journal of Cancer. Journal International Du Cancer·Minoru FukuchiHiroyuki Kuwano

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Citations

Dec 31, 2008·Cell Research·Julien Deheuninck, Kunxin Luo
Nov 2, 2012·Fibrogenesis & Tissue Repair·Michael P Czubryt
Feb 23, 2011·The Journal of Pathology·Ping LiYuan-Guo Zhou
Nov 6, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Leah C BiggsMartine Dunnwald
Apr 4, 2016·Biochimica Et Biophysica Acta·Matthew R ZeglinskiIan M C Dixon
Jun 7, 2011·The American Journal of Pathology·Stephanie ArndtAnja-Katrin Bosserhoff
Oct 3, 2008·Gynecologic Oncology·Marie N MenkeRobert F Diegelmann
Oct 12, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jun LiShuang-Shuang Dai
Aug 25, 2006·Gene Therapy·L K BranskiM G Jeschke
Jun 13, 2018·Signal Transduction and Targeted Therapy·Angeles C Tecalco-CruzMarina Macías-Silva

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