Expression and prognostic implications of apoptosis-related proteins in locally unresectable non-small cell lung cancers

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Eelco FokkemaH J M Groen

Abstract

Apoptosis related proteins in early staged NSCLC seem to have prognostic value. We studied the value of a combination of eight of those proteins in advanced NSCLC. Bronchoscopically procured tumor biopsies of NSCLC patients were stained immunohistochemically and rated for expression of eight different cellular proteins. Patients were treated with 60 Gy radiotherapy with or without carboplatin as radiosensitizer. Apoptotic proteins in tumors that showed positive staining were the highest for Bax (99%), Fas (92%), FasL (87%), Rb (87%), p21(WAF1) (73%), and p53 (70%), and the lowest for c-myc (58%) and Bcl-2 (58%). In the Cox regression analysis Bcl-2 positivity (RR = 0.61, 95% CI, 0.37-0.98, p = 0.04) was predictive for overall survival. Only Bcl-2 staining percentage (RR(10) (RR associated with an increase in stained cells of 10%) = 0.93, 95% CI, 0.89-0.99), p53 (RR(10) = 0.94, 95% CI, 0.89-0.99) and FasL (RR(10) = 0.92, 95% CI, 0.86-0.99) were predictive for a longer progression-free survival. No specific constellation of apoptotic proteins was associated with tumor response. Bcl-2 expression in tumor tissue of patients with unresectable NSCLC predicts a better overall survival, while Bcl-2, p53, and FasL expressions predict fo...Continue Reading

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Citations

Jul 19, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lars Henning SchmidtRainer Wiewrodt
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·José L MoreroMoisés Rosenberg
Dec 29, 2009·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·J H StegehuisF A E Kruyt
Apr 17, 2009·Medicina clínica·Ricardo García LujánAngel López Encuentra
Jun 30, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Seong Hyun JeongSeung Soo Sheen
Jan 7, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anne-Claire ToffartElisabeth Brambilla
Feb 7, 2015·Cell Death and Differentiation·M E PeterP Ceppi
May 22, 2019·Cancers·Arik Bernard SchulzeLars Henning Schmidt

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