Expression and prognostic relevance of CD44v6 in stage I non-small cell lung carcinoma.

Journal of Cancer Research and Clinical Oncology
Dongrong SituTiehua Rong

Abstract

Expression of CD44 and its variants has been shown to be relevant to tumor progression in various human malignancies. We evaluated the expression of CD44v6 in the primary lesions of stage I non-small cell lung cancer (NSCLC) and correlated the expression level to its prognosis. The expression of CD44v6, measured by immunohistochemistry, was assessed in the tumor specimens from 190 patients with stage I NSCLC. Each slide was assigned a score: the average of the score of tumor cells staining multiplied by the score of staining intensity. And depending on the cut-off score based on receiver operating characteristic (ROC) curve analysis, the CD44v6 expression was categorized into high- and low-level groups, which were then correlated directly with the clinical outcomes. The high expression of CD44v6 was detected more frequently in the squamous cell carcinoma (38 of 71 patients, 53.5%) than in the other types of carcinoma (p < 0.05). The Kaplan-Meier survival curves showed that high level expression of CD44v6 indicated a better post-operative survival (p = 0.006), especially for stage IB disease (p = 0.049) and squamous cell carcinoma (p = 0.029). The multivariate analysis also confirmed that the expression of CD44v6 was an independ...Continue Reading

References

Sep 1, 1991·Chest·M S Bains
Jun 22, 1995·International Journal of Cancer. Journal International Du Cancer·E Manten-HorstD J Ruiter
Mar 1, 1996·Journal of Clinical Gastroenterology·H J HarnW H Lee
Jan 1, 1997·Advances in Cancer Research·D NaorD Ish-Shalom
Mar 1, 1997·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A WimmelM Schuermann
Apr 1, 1997·Molecular Pathology : MP·Z Rudzki, S Jothy
Aug 1, 1997·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·T MiyoshiY Monden
Oct 26, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hiroaki Suzuki, Katsushige Yamashiro
Nov 8, 2003·World Journal of Gastroenterology : WJG·Wei-Guo DongJie-Ping Yu
Jan 23, 2004·The New England Journal of Medicine·Alexander Spira, David S Ettinger
Jul 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Danila CoradiniAlberto Perbellini
Sep 2, 2004·Journal of Molecular Histology·R Marhaba, M Zöller
Jun 21, 2007·Molecular Cancer Research : MCR·Sebastian KuhnMargot Zöller
Feb 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zhi-Hua ZhuTie-Hua Rong

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Citations

Nov 5, 2010·World Journal of Gastroenterology : WJG·Dong-Rong SituTie-Hua Rong
Jun 11, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hao JiangWei Shao
Apr 14, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Heather MaleFaris Farassati
Sep 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Anu YadavBalraj Mittal
Apr 7, 2012·Pathology Research International·Dang-Xia ZhouYa-Hong Xue
Mar 20, 2018·Oncology Letters·Bo HuJinfeng Chen
Feb 1, 2013·Molecular Cancer Research : MCR·Paul G DaftMajd Zayzafoon
Apr 24, 2021·Signal Transduction and Targeted Therapy·Jiacheng HuangYiting Qiao

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