Abstract
Expression of CD44 and its variants has been shown to be relevant to tumor progression in various human malignancies. We evaluated the expression of CD44v6 in the primary lesions of stage I non-small cell lung cancer (NSCLC) and correlated the expression level to its prognosis. The expression of CD44v6, measured by immunohistochemistry, was assessed in the tumor specimens from 190 patients with stage I NSCLC. Each slide was assigned a score: the average of the score of tumor cells staining multiplied by the score of staining intensity. And depending on the cut-off score based on receiver operating characteristic (ROC) curve analysis, the CD44v6 expression was categorized into high- and low-level groups, which were then correlated directly with the clinical outcomes. The high expression of CD44v6 was detected more frequently in the squamous cell carcinoma (38 of 71 patients, 53.5%) than in the other types of carcinoma (p < 0.05). The Kaplan-Meier survival curves showed that high level expression of CD44v6 indicated a better post-operative survival (p = 0.006), especially for stage IB disease (p = 0.049) and squamous cell carcinoma (p = 0.029). The multivariate analysis also confirmed that the expression of CD44v6 was an independ...Continue Reading
References
Apr 5, 1991·Cell·U GünthertP Herrlich
Sep 1, 1991·Chest·M S Bains
Jan 12, 1990·Cell·T St JohnW M Gallatin
Mar 24, 1989·Cell·I StamenkovicB Seed
Nov 26, 1994·Lancet·J W MulderS T Pals
Mar 11, 1995·Lancet·M KaufmannP Herrlich
Jun 22, 1995·International Journal of Cancer. Journal International Du Cancer·E Manten-HorstD J Ruiter
Jan 1, 1996·Cancer·T MiwaH Nakano
Mar 1, 1996·Journal of Clinical Gastroenterology·H J HarnW H Lee
Jan 1, 1997·Advances in Cancer Research·D NaorD Ish-Shalom
Mar 1, 1997·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A WimmelM Schuermann
Jul 1, 1997·Human Pathology·T A TranJ S Ross
Apr 1, 1997·Molecular Pathology : MP·Z Rudzki, S Jothy
Aug 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Aug 1, 1997·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·T MiyoshiY Monden
Dec 13, 2000·The Journal of Pathology·S RamasamiR R Jeffrey
Oct 26, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hiroaki Suzuki, Katsushige Yamashiro
Nov 8, 2003·World Journal of Gastroenterology : WJG·Wei-Guo DongJie-Ping Yu
Jan 23, 2004·The New England Journal of Medicine·Alexander Spira, David S Ettinger
Jul 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Danila CoradiniAlberto Perbellini
Sep 2, 2004·Journal of Molecular Histology·R Marhaba, M Zöller
Dec 22, 2006·Journal of Clinical Pathology·Inti ZlobecAlessandro Lugli
Jun 21, 2007·Molecular Cancer Research : MCR·Sebastian KuhnMargot Zöller
Feb 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zhi-Hua ZhuTie-Hua Rong
Citations
Aug 9, 2011·BMC Cancer·Yoon Ho KoJin Hyoung Kang
Apr 5, 2014·PloS One·Ying-Erh ChouChiao-Wen Lin
Nov 5, 2010·World Journal of Gastroenterology : WJG·Dong-Rong SituTie-Hua Rong
Jun 11, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hao JiangWei Shao
Apr 14, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Heather MaleFaris Farassati
Apr 26, 2011·Oral Oncology·Linda-Lotta KokkoSami Ventelä
Jan 1, 2015·Respiratory Research·Emily Van de LaarNadeem Moghal
Sep 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Anu YadavBalraj Mittal
Apr 7, 2012·Pathology Research International·Dang-Xia ZhouYa-Hong Xue
Mar 30, 2012·PloS One·Lou Qian ZhangRong Yin
Aug 31, 2016·Molecular Medicine Reports·Guanghu LiJingwei Shi
Oct 4, 2019·Oncology Letters·Yudong WuBaojun Wang
Mar 20, 2018·Oncology Letters·Bo HuJinfeng Chen
Apr 19, 2018·Journal of Human Genetics·Zahra FathiRaheleh Roudi
Feb 6, 2020·Proteomics. Clinical Applications·Hsin-Yi WuPao-Chi Liao
Feb 1, 2013·Molecular Cancer Research : MCR·Paul G DaftMajd Zayzafoon
Oct 29, 2010·Cancer Research·Vinit KumarGopal C Kundu
Apr 24, 2021·Signal Transduction and Targeted Therapy·Jiacheng HuangYiting Qiao