Expression and prognostic significance of the P53-related DNA damage repair proteins checkpoint kinase 1 (CHK1) and growth arrest and DNA-damage-inducible 45 alpha (GADD45A) in human oral squamous cell carcinoma

European Journal of Oral Sciences
Liping XieJinhua Zheng

Abstract

DNA damage repair is a key factor in the maintenance of cell genome stability, plays an important role in the regulation of tumour evolution, and can affect the prognosis of cancer patients. This study aimed to detect the protein expression of the DNA damage repair protein P53 and its upstream and downstream regulators, CHK1, GADD45A, and MDM2, in oral squamous cell carcinoma (OSCC), in order to analyse the association between the expression of these proteins and overall survival, and to assess their prognostic implications for OSCC patients. The expression of the above proteins was detected by immunohistochemistry in 80 human OSCC tissue samples and in non-cancerous tissue samples. Compared to that in the non-cancerous tissue, the expression of CHK1, GADD45A, and MDM2 in OSCC tissue was significantly increased. The protein expression of the tumour suppressor gene P53 was also increased. Patients with high CHK1 and MDM2 expression levels had a reduced survival time and a poor prognosis, whereas patients with high GADD45A expression levels had a good prognosis. Our results indicate that high CHK1 expression is an independent risk factor for poor OSCC prognosis, and that CHK1 may be a potential target for OSCC clinical treatment.

References

Apr 1, 1996·Human Genetics·H BlaszykJ S Kovach
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·J L KoH Lee
Nov 4, 2000·Cell Proliferation·P Campomenosi, P A Hall
Sep 6, 2002·Oncogene·M Christine Hollander, Albert J Fornace
Nov 25, 2003·Oncogene·Shunqian JinQimin Zhan
Sep 3, 2005·Molecular Cell·You-Wei ZhangRobert T Abraham
Dec 20, 2005·Current Biology : CB·Veronique A J SmitsStephen P Jackson
May 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sreekanth P ReddyM R Satyanarayana Rao
Sep 2, 2008·The International Journal of Biochemistry & Cell Biology·A Rosemary Siafakas, Des R Richardson
May 20, 2009·Cell·Jan-Philipp Kruse, Wei Gu
Dec 22, 2009·Cell Cycle·Callie MerryYouwei Zhang
Jan 14, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yun Dai, Steven Grant
Feb 23, 2010·Trends in Cell Biology·Mark WadeGeoffrey M Wahl
Oct 26, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Zhuang ZhangNingyi Li
Mar 1, 2012·The Journal of Experimental Medicine·Andres J López-ContrerasOscar Fernandez-Capetillo
May 16, 2012·The Journal of Clinical Investigation·Jian HongTiebang Kang
Jun 14, 2012·The Journal of Biological Chemistry·Jingna WangYouwei Zhang
Dec 25, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qin Li, Guillermina Lozano
Apr 25, 2013·International Journal of Cancer. Journal International Du Cancer·Youwei Zhang, Tony Hunter
Jan 30, 2015·Nature·UNKNOWN Cancer Genome Atlas Network
Sep 12, 2015·Critical Reviews in Oncology/hematology·Loredana UrsoGiulia Pasello
Mar 10, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Angela HongBarbara Rose
Dec 3, 2016·Critical Reviews in Therapeutic Drug Carrier Systems·Sankalp A GharatChintan Bhavsar
Jul 27, 2017·Expert Opinion on Investigational Drugs·Hani M BabikerDaruka Mahadevan
Sep 30, 2017·Cancer Treatment Reviews·Laura Carrassa, Giovanna Damia
Mar 1, 2018·Journal of Dental Research·A LindemannJ N Myers
Oct 2, 2019·OncoTargets and Therapy·Na HanGangjun Yuan

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