PMID: 9421352Jan 8, 1998Paper

Expression and prognostic significance of immunoregulatory molecules in esophageal cancer

International Journal of Cancer. Journal International Du Cancer
S B HoschK Pantel

Abstract

Major histocompatibility complex molecules (HLA), the co-stimulatory molecule B7 and the intercellular adhesion molecule 1 (ICAM-1) are key molecules involved in T cell-mediated immune surveillance. We aimed at assessing the expression pattern of these immunoregulatory molecules on primary esophageal carcinomas and evaluating their prognostic significance. Representative samples of primary tumors were obtained from 53 patients who had undergone radical en bloc esophagectomy without residual tumor. Cryostat sections of these tumors were stained with monoclonal antibodies (MAbs) directed against either HLA class I, HLA class II, B7 or ICAM-1. The median follow-up was 19 months (range, 6-43). We found that HLA class I expression was deficient on 27 tumors, while a significant neo-expression of HLA class II, B7 and ICAM-1 (> or =25% positive tumor cells) was observed on 17, 29 and 25, tumors, respectively. Kaplan-Meier analyses revealed a significant beneficial influence on relapse-free survival for patients with tumors expressing HLA class I, HLA class II and B7. Cox's regression analyses demonstrated that co-expression of HLA class I and ICAM-1 was a significant and independent predictor of a reduced risk of developing tumor recu...Continue Reading

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Citations

Mar 26, 2005·Journal of Clinical Pathology·K S NairR Chetty
Oct 16, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giang Huong NguyenCurtis C Harris
Aug 31, 1999·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J O'ConnellF Shanahan
Jul 30, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Akiko TachimoriKosei Hirakawa
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Yukinobu MaruoKunzo Orita
Mar 19, 1999·Immunology Today·J O'ConnellF Shanahan
Jun 2, 2005·World Journal of Gastroenterology : WJG·Wei ChenXia Wang
Mar 1, 2018·Cancer Immunology, Immunotherapy : CII·Lei CaiSoldano Ferrone
Jan 18, 2006·Digestive Diseases and Sciences·Masakazu YashiroKosei Hirakawa
Aug 25, 2010·Annals of Surgical Oncology·Yoshiaki KitaMasaki Mori
Mar 14, 2020·Cancer Science·Kazushige KoikeAkihiro Miyazaki
Jun 20, 2020·World Journal of Gastroenterology : WJG·Preeti SharmaShanmugarajah Rajendra
Mar 20, 2012·Journal of Cancer Research and Clinical Oncology·Arfon G M T PowellJoanne Edwards
Oct 27, 2020·Annals of the New York Academy of Sciences·Shanmugarajah RajendraShweta Dutta Gautam

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