Expression and prognostic value of miRNA-29b in peripheral blood for endometrial cancer.

Future Oncology
Hui WangXiu-Ping Lv

Abstract

We explored the role of miR-29b expression in endometrial cancer (EC) progression and patient prognosis. Patients with primary or metastatic EC (n = 356), patients with endometrial benign tumors (n = 149) and healthy female subjects (n = 155) were collected. We assessed the diagnostic value of miR-29b expression for EC using a receiver operating characteristic curve. The miR-29b expressions were lower in patients with primary or metastatic EC. Using miR-29b expression to diagnose EC produced 0.976 area under the curve, 96.1% sensitivity and 97.9% specificity. Cox proportional hazard regression model verified a low miR-29b expression and is an unfavorable prognostic indicator for EC. We conclude that downregulated miR-29b expression correlates with poor EC prognosis and is helpful to evaluate the EC prognosis.

References

Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M E Sherman
Dec 24, 2002·Yonsei Medical Journal·Jae Wook KimDong Kyu Kim
Sep 17, 2004·Nature·Victor Ambros
Oct 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jonathan L Hecht, George L Mutter
Mar 17, 2007·Pathology·Jaime PratLluis Catasús
Sep 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Muller FabbriCarlo M Croce
Jan 12, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Marjorie L McCulloughEugenia E Calle
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eva van RooijEric N Olson
Apr 4, 2009·The Journal of Biological Chemistry·Zhaoyong LiJane B Lian
Apr 16, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Sergio Pecorelli
Jul 21, 2009·Biochemical Society Transactions·S Duygu SelcukluCharles Spillane
Nov 12, 2009·Gynecologic Oncology·Paola A Gehrig, Victoria L Bae-Jump
Jul 29, 2010·Genes, Chromosomes & Cancer·Maria Angelica CortezGeorge Adrian Calin
Nov 18, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Tung NguyenDave S B Hoon
Jul 26, 2011·Journal of the American Society of Nephrology : JASN·Wei QinHui Y Lan
Nov 25, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nigel B JamiesonKarin A Oien
Apr 18, 2012·Gynecologic Oncology·Kristy K WardSteven C Plaxe
Oct 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ColomboUNKNOWN ESMO Guidelines Working Group
Feb 28, 2014·Oncology Reports·Hesong JiangChun-Ping Jiang
Mar 29, 2014·Oncology Reports·Roberto BerrettaSalvatore Gizzo
May 30, 2014·The Lancet Oncology·Rajmohan MuraliBritta Weigelt
Nov 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Hao LiuLiang Zhao
Feb 20, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giovanni FaveroAchim Schneider
Apr 19, 2015·BMC Research Notes·Benjamin UlfenborgBjörn Olsson
Jun 6, 2015·International Journal of Oncology·Hong-Yan WangYa-Jie Zhang
Jul 23, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan-Ying XuLi-Rong Yin
Oct 2, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Reza BahadorPeyman Karimi Goudarzi
Aug 16, 2016·Genetics and Molecular Research : GMR·C W DongS Y Hu
Feb 22, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hong-Xia ChenXiao-Dong Zhou

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Citations

Jul 25, 2018·International Journal of Molecular Sciences·Alessandro La FerlitaCinzia Di Pietro

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Methods Mentioned

BETA
hormone replacement therapy
PCR
reverse transcription-PCR
surgical resection

Software Mentioned

SPSS

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