Expression and protective effects of urocortin in cardiac myocytes

Neuropeptides
A OkosiRichard A Knight

Abstract

Reverse transcription PCR showed that mRNA encoding the CRH-like molecule, urocortin, is expressed in a rat cardiac myocyte cell line and in primary cultures of cardiac myocytes. Identity of the amplified with the published sequence was established by restriction mapping and direct sequencing. Expression of urocortin mRNA was increased 12-18 h after thermal injury. Urocortin peptide protected cardiac myocytes from cell death induced by hypoxia. The data suggest that urocortin is an endogenous cardiac myocyte peptide which modulates the cellular response to stress.

References

Aug 1, 1992·Journal of Molecular and Cellular Cardiology·D M YellonR Ferrari
Feb 1, 1992·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M GruntE F Pfeiffer
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R ChenW W Vale
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·T W LovenbergT Oltersdorf
Jul 1, 1993·Stroke; a Journal of Cerebral Circulation·M W FoxF B Meyer
Sep 1, 1996·Endocrinology·C J DonaldsonW W Vale
Oct 1, 1996·The Journal of Clinical Endocrinology and Metabolism·F PetragliaW Vale

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Citations

Sep 9, 2008·Archives of Gynecology and Obstetrics·C IavazzoA Malamitsi-Puchner
May 23, 2007·Heart Failure Reviews·Dwaine S BurleyGary F Baxter
Apr 16, 2003·European Journal of Pharmacology·Aly M Abdelrahman, Catherine C Y Pang
Aug 15, 2002·Life Sciences·Keiichi IkedaKazuwa Nakao
Jan 11, 2001·Peptides·A J KastinW Pan
May 5, 2001·Peptides·D G ParkesC N May
Jan 12, 2000·Molecular and Cellular Endocrinology·B K BrarD S Latchman
Dec 13, 2000·Brain Research Bulletin·M ShiR B Harris
Jul 10, 2002·Journal of the American College of Cardiology·Tiziano M ScarabelliDavid S Latchman
Oct 24, 2002·Journal of the American College of Cardiology·Miriam T RademakerWylie W Vale
Oct 13, 2001·Trends in Cardiovascular Medicine·D S Latchman
Jun 19, 2002·Trends in Cardiovascular Medicine·Sarah C CosteMary P Stenzel-Poore
May 15, 2002·The International Journal of Biochemistry & Cell Biology·David S Latchman
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Tracy L Bale, Wylie W Vale
May 8, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Paul A TownsendAndrew P Halestrap
May 2, 2012·International Journal of Endocrinology·Keiichi IkedaKatsuyoshi Tojo
Jun 8, 2012·International Journal of Endocrinology·Kazuhiro Takahashi
Oct 1, 2010·Experimental Biology and Medicine·Andreas Stengel, Yvette Taché
Mar 25, 2009·Pharmacological Reports : PR·Sean M Davidson, Derek M Yellon
Jun 22, 2011·Journal of Molecular and Cellular Cardiology·Theophilus I EmetoJonathan Golledge
Apr 27, 2010·Molecular and Cellular Endocrinology·Zhaokan YuanTiziano M Scarabelli
Apr 22, 2009·Drug Discovery Today·Konstantinos A PaschosEkaterini Chatzaki
Apr 16, 2009·General and Comparative Endocrinology·Sarah L Alderman, Nicholas J Bernier
Sep 27, 2008·Biochemical Pharmacology·Sean M DavidsonPaul A Townsend
Feb 13, 2008·Biochemical and Biophysical Research Communications·Cui YangShengnan Li
Jan 9, 2008·International Journal of Cardiology·Phitsanu BoonprasertNipon Chattipakorn
Jul 28, 2004·American Journal of Reproductive Immunology : AJRI·Mei Y ChoyTze K Lau
Jul 5, 2003·The Journal of Pharmacy and Pharmacology·Elena SanzAngel Luis Garcia-Villalón
Jan 24, 2006·Biochemical and Biophysical Research Communications·Yuqing WuShengnan Li
Oct 2, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jin TaoShengnan Li
Aug 4, 2004·European Journal of Pharmacology·Nimesh S A PatelChristoph Thiemermann
Mar 2, 2005·Biochemical and Biophysical Research Communications·Jin TaoShengnan Li
Feb 21, 2006·Vascular Pharmacology·Cui YangShengnan Li
Aug 3, 2005·Biochemical and Biophysical Research Communications·Jin Tao, Shengnan Li

❮ Previous
Next ❯

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