Expression and putative function of lymphocyte endothelial epithelial-cell adhesion molecule in human testis

Andrologia
B G WienrichM P Schön

Abstract

The testis is an immunologically privileged site where germ cell antigens are protected from autoimmune attack and foreign tissue grafts may survive for extended periods. However, the testicular environment does not preclude inflammatory reactions and tissue-specific recruitment of T lymphocytes appears to be a crucial component of the inflammation cascade. Here, we demonstrate expression of lymphocyte endothelial epithelial-cell adhesion molecule (LEEP-CAM), a putative receptor mediating lymphocyte adhesion to endothelia and some epithelia, in human testis. In all specimens examined, expression of LEEP-CAM could be observed on endothelial cells of testicular blood vessels, including those within the lamina propria of seminiferous tubules. Sections of histologically normal testis showed strong LEEP-CAM expression within the seminiferous epithelium localised to Sertoli cells, whereas immunoreactivity was almost absent in tubules with severely impaired spermatogenesis. In a modified Stamper-Woodruff adhesion assay, binding of activated lymphocytes to normal testicular tissue was reduced by 61% after incubation with anti-LEEP-CAM mAb as compared with controls (P < 0.00001). In conclusion, intratubular LEEP-CAM expression is correl...Continue Reading

References

Oct 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·G G HaasL E De Bault
Sep 1, 1987·Fertility and Sterility·M I el-DemiryG D Chisholm
Sep 1, 1985·Transplantation·J R Head, R E Billingham
Oct 1, 1983·Transplantation·J R HeadR E Billingham
Jan 1, 1984·Acta Anatomica·M NistalR Paniagua
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·A RiccioliE Ziparo
Nov 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·O BraendstrupO Werdelin
Jan 1, 1995·Human Reproduction Update·K S Tung, C Teuscher
Jul 1, 1997·Journal of Reproductive Immunology·S Sainio-PöllänenP Pöllänen
Jan 1, 1997·Reviews of Reproduction·M P Hedger
Jun 22, 1999·Human Reproduction·S SchlattE Nieschlag
Sep 15, 2001·Human Reproduction Update·A FilippiniE Ziparo
Jun 22, 2002·Science·Ralph L Brinster
Jul 26, 2002·Fertility and Sterility·Mónica B FrungieriArtur Mayerhofer
Oct 19, 2002·Journal of Reproductive Immunology·Mark P Hedger
Dec 3, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Steven Goossens, Frans van Roy
Sep 16, 2006·Immunological Reviews·Monika Fijak, Andreas Meinhardt
Jan 16, 2007·Neoplasia : an International Journal for Oncology Research·Cornelia FinkRalph H Brehm
Aug 25, 2007·Nature Reviews. Immunology·Klaus LeySussan Nourshargh
Oct 16, 2007·Current Opinion in Cell Biology·Alpha S YapJeff Hardin
Mar 14, 2008·Andrologia·H-C SchuppeG Haidl

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Citations

Dec 31, 2020·International Journal of Molecular Sciences·Jialei GongYong-Gang Duan

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