Expression and putative role of lactoseries carbohydrates present on NCAM in the rat primary olfactory pathway

The Journal of Comparative Neurology
Melonie Joanne StoranBrian Key

Abstract

Primary olfactory neurons project axons from the olfactory neuroepithelium lining the nasal cavity to the olfactory bulb in the brain. These axons grow within large mixed bundles in the olfactory nerve and then sort out into homotypic fascicles in the nerve fiber layer of the olfactory bulb before terminating in topographically fixed glomeruli. Carbohydrates expressed on the cell surface have been implicated in axon sorting within the nerve fiber layer. We have identified two novel subpopulations of primary olfactory neurons that express distinct alpha-extended lactoseries carbohydrates recognised by monoclonal antibodies LA4 and KH10. Both carbohydrate epitopes are present on novel glycoforms of the neural cell adhesion molecule, which we have named NOC-7 and NOC-8. Primary axon fasciculation is disrupted in vitro when interactions between these cell surface lactoseries carbohydrates and their endogenous binding molecules are inhibited by the LA4 and KH10 antibodies or lactosamine sugars. We report the expression of multiple members of the lactoseries binding galectin family in the primary olfactory system. In particular, galectin-3 is expressed by ensheathing cells surrounding nerve fascicles in the submucosa and nerve fiber ...Continue Reading

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Citations

Mar 4, 2006·Journal of Molecular Histology·Fatemeh ChehrehasaBrian Key
Dec 24, 2005·Journal of Neurocytology·Adele J VincentMeng Inn Chuah
Dec 3, 2008·Molecular Neurobiology·Jin Hyung ChoJean-François Cloutier
Apr 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Timothy R HenionGerald A Schwarting
Feb 10, 2010·Cellular and Molecular Life Sciences : CMLS·Louisa C E WindusJames A St John
Sep 30, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Curtis W Balmer, Anthony-Samuel LaMantia
Mar 21, 2012·Glia·Mirjana StancicWia Baron
Mar 28, 2016·Protein & Cell·Zhan-Qi Cao, Xiu-Li Guo
Oct 5, 2010·Molecular and Cellular Neurosciences·Caroline ChanJames A St John
Jun 28, 2011·Molecular and Cellular Neurosciences·Katie E LineburgJames A St John
Feb 21, 2006·International Review of Cytology·Martin Witt, Thomas Hummel
Jul 29, 2006·The Journal of Comparative Neurology·Olga LévaiJoerg Strotmann
Nov 18, 2006·Journal of Cellular Physiology·Timothy R Henion, Gerald A Schwarting
Mar 4, 2017·Journal of Molecular Histology·Hong-Il YooDae-Yong Song
Aug 28, 2021·European Journal of Pharmacology·Michelle Melgarejo da RosaMaira Galdino da Rocha Pitta

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