Expression and regulation of galectin 3 in rat osteoblastic cells

Journal of Cellular Physiology
J E AubinK Turksen

Abstract

Galectin 3 is an endogenous soluble beta-galactoside-specific lectin originally identified and termed epsilon BP or IgE-binding protein in rat basophilic leukemia cells, but its wide tissue distribution and the multiple contexts in which it has been isolated have suggested that its function may not be limited to IgE binding but may include a role in cell growth regulation and differentiation, neoplastic transformation, and cell adhesion (Liu, 1990, Crit. Rev. Immunol., 10:289-306; Barondes et al., 1994, J. Biol. Chem., 269:20807-20810). After immunoscreening of a lambda gt11 cDNA expression library made from bone-nodule forming cultures of fetal rat calvaria (RC) cells with an antibody raised against osteoblastic cells (Turksen et al., 1992, J. Histochem. Cytochem., 40:1339-1352), three cDNA clones were isolated and sequenced; the sequence matched that of rat galectin 3. Galectin 3 mRNA was detected in various fetal and adult rat tissues, including calvaria and cultured RC cells. In RC cells and the rat osteosarcoma cell line ROS 17/2.8, galectin 3 mRNA expression increased with time in culture, in contrast to its behavior in fetal rat skin fibroblasts (RSF) in which its expression decreased with time in culture. In a second ra...Continue Reading

References

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Citations

Aug 16, 2012·In Vitro Cellular & Developmental Biology. Animal·Sanja DabelicJerka Dumic
Aug 1, 1995·Bone·J E AubinA K Gupta
Dec 11, 2008·Journal of the Royal Society, Interface·Fahsai KantawongMatthew J Dalby
Oct 20, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Harutsugi AbukawaMaria J Troulis
Jun 8, 2012·Journal of Cellular Physiology·Jung-Min KimPann-Ghill Suh
May 31, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Yong HuPascal Reboul
Nov 22, 2017·International Journal of Molecular Sciences·Carla IacobiniStefano Menini
Feb 27, 2003·The Journal of Biological Chemistry·Michael StockFlorian Otto
Feb 1, 1996·Microscopy Research and Technique·J E Aubin, K Turksen
Apr 10, 1997·Experimental Cell Research·F LiuJ E Aubin

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