Expression and regulation of steroid 5 alpha-reductase in the urogenital tract of the fetal rat

Molecular Endocrinology
D M BermanD W Russell

Abstract

Two androgens, testosterone and dihydrotestosterone, are required for the development of the male urogenital tract in the rat. Testosterone is secreted by the fetal testes and is thought to elicit differentiation of the Wolffian ducts into seminal vesicles, vas deferens, and epididymides. Testosterone is converted into dihydrotestosterone by steroid 5 alpha-reductase in the urogenital tract, and this conversion is necessary for the differentiation of the prostate and external genitalia. Genes encoding two 5 alpha-reductase isozymes, designated type 1 and type 2, have been identified. We examined the expression and regulation of these genes on days 17-21 in the urogenital tracts of male and female fetuses. Expression of the type 1 gene predominated in epithelial cells, whereas type 2 gene expression was limited to mesenchymal cells. Surprisingly, this expression pattern was detected in both testosterone-dependent and dihydrotestosterone-dependent anlagen of the urogenital tract and was the same in both male and female fetuses. Furthermore, transcripts encoding the two isozymes were present in their respective cell types before the overt differentiation of internal genitalia. Androgens stimulated expression of the type 2 gene in ...Continue Reading

Citations

May 27, 2009·Indian Journal of Urology : IJU : Journal of the Urological Society of India·C RadmayrG Bartsch
Dec 30, 2006·Molecular and Cellular Endocrinology·Yannick BlanchardBernard Robaire
Aug 24, 1999·The Journal of Urology·R I Silver, D W Russell
Mar 12, 2004·Developmental Biology·David M BermanMichael M Shen
Mar 19, 2016·General and Comparative Endocrinology·Sonja Bissegger, Valerie S Langlois

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