Expression and Regulation of Transcription Factor FoxA2 in Chronic Rhinosinusitis With and Without Nasal Polyps

Allergy, Asthma & Immunology Research
Qing LuoHuabin Li

Abstract

Chronic rhinosinusitis (CRS) is characterized by the excessive production of mucus. However, the molecular mechanism underlying mucin overproduction in CRS with or without nasal polyps (CRSwNP and CRSsNP, respectively) is poorly understood. This study was conducted to assess the importance of the transcription factor FoxA2 in mucin production and to investigate the targeting of FoxA2 as a potential therapeutic strategy for mucus hypersecretion in CRS patients. We enrolled 15 CRSwNP patients, 15 CRSsNP patients, and 10 normal controls in this study. The expression levels of FoxA2, MUC5AC, and MUC5B in inflamed and healthy nasal tissues were examined via immunohistochemistry and quantitative reverse transcription-polymerase chain reaction, and the levels of several proinflammatory cytokines in nasal secretions were measured via FlowCytomix analysis. In addition, the expression of MUC5AC and FoxA2 was determined in polyp-derived epithelial cells and NCI-H292 cells after in vitro stimulation. FoxA2 was significantly down-regulated, and MUC5AC and MUC5B were significantly up-regulated in both the CRSwNP and CRSsNP patients compared to the controls (P<0.05), and the protein level of FoxA2 was negatively associated with the IL-6 level...Continue Reading

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Citations

Oct 17, 2015·Nature Reviews. Drug Discovery·Namita A GandhiGeorge D Yancopoulos
Jan 29, 2020·Expert Review of Clinical Immunology·Chengshuo WangLuo Zhang
Aug 31, 2019·American Journal of Rhinology & Allergy·Danqing YanQing Luo
Mar 21, 2019·American Journal of Rhinology & Allergy·Kosuke KatoEugene H Chang
Jul 25, 2019·Allergy, Asthma & Immunology Research·Yi Sook KimHyun Woo Shin

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Methods Mentioned

BETA
light microscopy
PCR
ELISA
transfection
electrophoresis
Infrared Imaging

Software Mentioned

Odyssey®

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