PMID: 11924718Apr 2, 2002Paper

Expression and role of angiotensin II type 2 receptor in the kidney and mesangial cells of spontaneously hypertensive rats

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Masahisa GotoK Nakao

Abstract

Angiotensin II type 2 (AT2) receptor is developmentally regulated and exerts antiproliferative and proapoptotic actions. Genetic ablation of this receptor in mice affects regulation of blood pressure, but the involvement of the AT2 receptor in the pathogenesis of hypertension remains unknown. In the present study, we examined developmental changes of angiotensin receptor subtypes in the kidney of stroke-prone spontaneously hypertensive rats (SHRSP), and compared them with those in normotensive Wistar-Kyoto rats (WKY). We also investigated the regulation and functional role of the AT2 receptor in cultured mesangial cells. Receptor binding and Northern blot analyses revealed that AT2 receptor expression is significantly lower in the SHRSP kidney than in the WKY kidney during the perinatal period, while AT1 receptor expression is not different between them. In WKY mesangial cells, AT2 receptor stimulation exerted a potent antiproliferative effect; this effect was not observed in SHRSP cells lacking the AT2 receptor expression. The expression of interferon regulatory factor (IRF)-1 paralleled the growth-dependent induction of AT2 receptor in WKY mesangial cells, and transfection of IRF-1 antisense oligonucleotide significantly supp...Continue Reading

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Citations

Apr 9, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·D HerrC Wulff
Mar 20, 2012·Maturitas·María Jesús Ramírez-ExpósitoJosé Manuel Martínez-Martos
Oct 8, 2003·British Journal of Pharmacology·Robert E WiddopTracey A Gaspari
May 20, 2015·European Journal of Pharmacology·Anukriti SinghBushra Ateeq
May 17, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Myung-Kul YumEun-Young Park
Jun 7, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yu-Yan FanAkira Nishiyama
Mar 29, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroaki MukawaTakayuki Ito
Apr 5, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuaki YokotaHirofumi Makino
Jul 31, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ken ImanishiKimio Tomita
Aug 11, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masaichi-Chang-Il LeeToshihiko Ozawa
Feb 8, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masaru IwaiMasatsugu Horiuchi
Apr 28, 2006·Journal of the Society for Gynecologic Investigation·G Angela MassmannJorge P Figueroa
Mar 18, 2005·Journal of Cardiovascular Pharmacology·Shinji KawaharaMasunori Matsuzaki
Mar 18, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Rui YangAlain G Dupont
Jul 1, 2017·Frontiers in Medicine·Claudio de LuciaGiuseppe Rengo

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