Expression and secretion of inhibin and activin in normal and neoplastic uterine tissues. High levels of serum activin A in women with endometrial and cervical carcinoma

The Journal of Clinical Endocrinology and Metabolism
F PetragliaW Vale

Abstract

Inhibins and activins are growth factors belonging to the transforming growth factor-beta) family and are known to influence cell proliferation and differentiation. Because transforming growth factor-beta is involved in physiological and tumoral changes of uterine tissues, the present study aimed to evaluate whether human normal and neoplastic endometrial and cervical epithelial cells express and secrete inhibin A, inhibin B, and activin A. To test this hypothesis, different approaches were used. By RT-PCR, the expression of specific messenger RNAs (mRNAs) for the inhibin alpha, activin betaA and betaB subunits, and activin receptor type II and type IIB was investigated: 1) in primary cultures of endometrial (stroma and epithelium) or cervical (epithelium) cells from healthy women; and 2) in specimens of endometrial or cervical carcinoma. To demonstrate a possible secretion of the proteins, dimeric inhibin A, inhibin B, and activin A were measured in culture medium of normal epithelial or stromal endometrial cells and in uterine washing fluid of healthy women or patients with endometrial adenocarcinoma. Levels of the proteins were also measured in serum of women with endometrial or cervical carcinoma. Cultured endometrial strom...Continue Reading

Citations

Nov 26, 2010·Reproductive Biology and Endocrinology : RB&E·Ioannis MylonasMarkus S Kupka
Dec 25, 2009·Journal of Molecular Histology·Florian BergauerIoannis Mylonas
May 17, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Silvia MangioniAnna Maria Di Blasio
Oct 3, 2007·Annals of Surgical Oncology·Keiji YoshinagaMasaki Mori
Jun 22, 2013·Cytokine & Growth Factor Reviews·Francesco Elia MarinoElspeth Gold
Dec 17, 2009·Archives of Gynecology and Obstetrics·Tanja KimmichIoannis Mylonas
Feb 26, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Christopher W SederDavid G Beer
Jul 6, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ioannis Mylonas
Feb 24, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ioannis MylonasKlaus Friese
Feb 10, 2009·Fertility and Sterility·Pasquale FlorioFelice Petraglia
Feb 14, 2007·Fertility and Sterility·Paulo B TorresFelice Petraglia
May 8, 2004·Molecular and Cellular Endocrinology·Pasquale FlorioFelice Petraglia
Jun 19, 2015·Fertility and Sterility·Patrizia CarrarelliFelice Petraglia
Dec 17, 2014·Cytokine·Rachel D WilliamsonLouise C Kenny
Jan 20, 2017·Pflügers Archiv : European journal of physiology·Kunihiro SakumaAkihiko Yamaguchi
Dec 13, 2018·Physiological Reviews·Enrrico BloiseFernando M Reis

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