Expression and significance of CDC25B, PED/PEA-15 in esophageal carcinoma

Cancer Biotherapy & Radiopharmaceuticals
Ming WangYu Lin

Abstract

To explore the role of CDC25B, PED/PEA-15 in the development of esophageal carcinoma and its influence on the prognosis. Fluorescence quantitative real-time PCR and immunohistochemistry methods were used to analyze the expression of CDC25B, PED/PEA-15 in esophageal carcinoma. Moreover, survival analysis was done using the Kaplan-Meier method. In 66 cases of esophageal cancer tissues, the relative content of CDC25B mRNA was 16.22 (13.93-18.90). The positive expression rate of CDC25B protein was 48.5%, significantly higher than normal mucosa tissues (0%) (p<0.01). The relative content of PED/PEA-15 mRNA was 12.47 (10.41-14.93). The positive expression rate of PED/PEA-15 protein was 68.2%, significantly higher than normal mucosa tissues (17.6%) (p<0.01). The CDC25B protein expression was correlated with differentiation grade and depth of invasion (p<0.05). The PED/PEA-15 protein expression was related to differentiation grade, lymph node metastasis, and depth of invasion (p<0.05). Survival analysis showed that the mean survival time of PED/PEA-15-positive expression group was lower compared with the negative expression group (χ(2)=5.549, p=0.018). Analysis of the relationship between CDC25B and PED/PEA-15 suggested that there was ...Continue Reading

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Citations

May 10, 2017·Cancer Biology & Therapy·Shruti BhargavaKumaravel Somasundaram
Jan 22, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Dan XiePengpeng Qu

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

Matlab7
Multiplex Quantitative PCR System
SPSS17

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