Expression and significance of circulating microRNA-31 in lung cancer patients

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Hai-Jun YanWei Gu

Abstract

The aim of this study was to investigate the expression level of circulating microRNA-31(miRNA-31) in lung cancer patients and its clinical significance. Real-time fluorescent quantitative PCR was utilized to detect the circulating miRNA-31 expression levels in 300 lung cancer patients and 300 health control subjects. The ROC curve was drawn to evaluate the diagnostic value of the circulating miRNA-31 expression levels in lung cancer. The 300 lung cancer patients were divided into a miRNA-31 low-expression group and a miRNA-31 high-expression group. A survival curve was drawn according to the Kaplan-Meier method to evaluate the prognostic value of the circulating microRNA-31 expression levels for lung cancer. The circulating miRNA-31 expression levels in the lung cancer patients (l.88±0. 67) increased significantly (P<0.001) compared to the healthy controls (0.58±0. 44). The area under the ROC curve drawn according to the circulating miRNA-31 expression levels was 0.785 (95% CI=0.486-0.763). When the critical value was 1.27, the sensitivity and specificity for lung cancer diagnosis according to the circulating miRNA-31 expression levels were 0.769 and 0.745, respectively. The difference in the survival curve between the miRNA-3...Continue Reading

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Citations

Apr 2, 2016·Medical Oncology·Chen ZhaoHonglei Chen
Apr 28, 2017·Biomolecular Concepts·Virginie Armand-Labit, Anne Pradines
Sep 1, 2020·Briefings in Bioinformatics·Xing ChenChi-Chi Zhu
Oct 27, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Hao DingXin Zhao
Mar 3, 2020·Life Sciences·Md Mahmodul Hasan Sohel
Dec 1, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Shen ZhongJürgen Borlak
May 23, 2021·Briefings in Bioinformatics·Xing ChenChi-Chi Zhu
Aug 10, 2021·Interdisciplinary Sciences, Computational Life Sciences·Ahmet Toprak, Esma Eryilmaz Dogan

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Methods Mentioned

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