PMID: 15363297Sep 15, 2004Paper

Expression and significance of estrogen receptor isoforms in the development of human breast carcinoma

Zhonghua wai ke za zhi [Chinese journal of surgery]
Shu WangZhi-rong Cui

Abstract

To investigate the estrogen receptors (ER)alpha and ERbeta expression and their relationship with clinicopathological parameters in human breast carcinoma. Samples were obtained from 30 breast carcinoma, reverse transcriptase polymerase chain reaction was used to measure the expression of ERalpha and ERbeta mRNA. ERalpha mRNA level was up-regulated in breast carcinoma tissue compared with adjacent normal tissue (t = 7.399, P < 0.01) while down-regulated in ERbeta. The relative ratio of ERalpha and ERbeta was decreased in normal tissue vs. carcinoma (t = 6.385, P < 0.01), in patients with lymph node metastasis vs. those without lymph node metastasis (t = 2.602, P < 0.05), in late stage carcinoma vs. early stage (t = 3.754, P < 0.05). ERalpha and ERbeta play divergent role in the development of human breast carcinoma.

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