Expression and significance of twist, E-cadherin, and N-cadherin in gastrointestinal stromal tumors.

Digestive Diseases and Sciences
Jie DingSenlin Chen

Abstract

Twist, a basic helix-loop-helix transcription factor, has been reported to play a key role in the metastatic progression of several types of cancer. To investigate the expression and clinical significance of Twist, E-cadherin, and N-cadherin in gastrointestinal stromal tumors (GISTs). The expression of Twist, E-cadherin, and N-cadherin in GISTs was determined by immunohistochemistry, and their relationship with clinicopathological characteristics was analyzed. The positive rates of Twist, E-cadherin, and N-cadherin in GISTs were 66.7 % (52/78), 35.9 % (28/78), and 75.6 % (59/78), respectively. Twist was expressed significantly more in GISTs with distant metastasis or local invasion (p < 0.05). Although E-cadherin was expressed significantly less in cases of GISTs with distant metastasis (p < 0.05), expression of N-cadherin did not differ significantly according to clinical and pathological characteristics (p > 0.05). Expression of Twist was correlated positively with E-cadherin (rs = -0.253, p = 0.026) and negatively with N-cadherin (rs = 0.245, p = 0.030). Twist was expressed significantly more and E-cadherin significantly less in GISTs with metastasis, and expression of both was closely related to metastasis of GISTs.

References

Sep 1, 1983·The American Journal of Surgical Pathology·M T Mazur, H B Clark
Apr 16, 1998·Nature·P GuilfordA E Reeve
Sep 15, 1999·Genes & Development·R MaestroG J Hannon
Jul 3, 2002·Human Pathology·Christopher D M FletcherSharon W Weiss
Jan 11, 2003·Science·Michael C HeinrichJonathan A Fletcher
Dec 17, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Michael G HouseMalcolm V Brock
Sep 7, 2004·The International Journal of Developmental Biology·Lara D M Derycke, Marc E Bracke
Jun 17, 2005·Cancer Research·Wai Kei KwokXianghong Wang
Sep 6, 2007·Neoplasia : an International Journal for Oncology Research·Natacha Entz-WerleFabienne Perrin-Schmitt
Dec 8, 2007·Biochemical and Biophysical Research Communications·Farhad VesunaVenu Raman
Dec 3, 2010·The Journal of Pathology·María Ángeles CastillaJosé Palacios
Jul 5, 2011·Oncotarget·Mark A Eckert, Jing Yang

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