Expression and subcellular localization of p42IP4/centaurin-alpha, a brain-specific, high-affinity receptor for inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate in rat brain

The European Journal of Neuroscience
M R KreutzG Reiser

Abstract

Recently emerging evidence suggests important roles for inositol polyphosphates and inositol phospholipids in neuronal Ca2+ signalling, membrane vesicle trafficking and cytoskeletal rearrangement. A prerequisite for a detailed physiological characterization of the signalling of both potential second messengers inositol-(1,3,4,5)-tetrakisphosphate (InsP4) and phosphatidylinositol-3,4,5-trisphosphate (PtdInsP3) in the nervous system is the precise cellular localization of their receptors. Based on the cDNA sequence of a recently cloned brain-specific receptor with high affinity for both InsP4 and PtdInsP3 (InsP4-PtdInsP3R), p42IP4/centaurin-alpha, we localized the mRNA and the protein in rat brain. In situ hybridization revealed a widespread expression of the InsP4-PtdInsP3R with prominent labelling in cerebellum, hippocampus, cortex and thalamus, which moreover is developmentally regulated. Using peptide-specific antibodies, the immunoreactivity was localized in the adult brain in the vast majority of neuronal cell types and probably also in some glial cells. Prominent immunoreactivity was found in axonal processes and in cell types characterized by extensive neurites. In the hypothalamus a subpopulation of parvocellular neurons...Continue Reading

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Citations

May 14, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Thomas H WassinkVal C Sheffield
Feb 27, 2008·Journal of Neurochemistry·Andrea HaaseGeorg Reiser
Oct 29, 2009·The FEBS Journal·Samuel ClokieAlastair Aitken
Dec 17, 2010·Journal of Neuroscience Research·Britta Bartelt Kirbach, Nikola Golenhofen
Feb 16, 2002·European Journal of Biochemistry·Thierry DuboisAlastair Aitken
May 18, 2007·Annual Review of Cell and Developmental Biology·Alison K Gillingham, Sean Munro
Feb 11, 2011·Molecular Biology of the Cell·Kazuho IkedaVladimir Rodionov
Dec 4, 2019·Life Science Alliance·Avery Van DuzerNaoki Oshimori
Nov 9, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yufeng TongHee-Won Park
Feb 5, 2003·Biochemical and Biophysical Research Communications·Thierry DuboisAlastair Aitken
Feb 22, 2005·Cellular Signalling·Uwe KnippschildMartin Stöter
Jun 15, 2007·European Journal of Cell Biology·Jacek Jaworski
Jul 20, 2007·Journal of Cell Science·Carlene D MooreAnne Theibert

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