PMID: 6166944May 1, 1981Paper

Expression and synthesis of murine immune response-associated (Ia) antigens by brain cells

Proceedings of the National Academy of Sciences of the United States of America
J P TingJ A Frelinger

Abstract

This paper provides biochemical and histochemical evidence that a fraction of murine brain cells express and synthesize Ia (Immune response-associated) antigens. Both I-A and I-E subregion products are detected on frozen sections of mouse brains by immunoperoxidase staining. Most of these Ia-bearing cells are located in white matter tracts and appear to be intrafascicular oligodendrocytes. In contrast, cells in the gray matter rarely display detectable Ia antigens on their cell surfaces. Specificity of the staining was confirmed by absorption studies. Biochemical evidence for the active synthesis of Ia antigens by brain cells was obtained by immunoprecipitation of [3H]leucine/tyrosine-labeled, NP-40-extracted cell lysates with monoclonal anti-Ia reagent. Both the alpha and beta subunits of Ia antigens were identified by NaDodSO4 electrophoresis. By contrast, anti-mu serum failed to precipitate any product, thus eliminating contaminant B lymphocytes as a source of Ia antigens.

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R M Steinman, M D Witmer
Nov 1, 1979·Nature·J G FrelingerJ A Frelinger
Sep 1, 1976·The Journal of Experimental Medicine·D B MurphyH O McDevitt
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Citations

Jan 1, 1983·Immunogenetics·J P TingJ A Frelinger
Jan 1, 1984·Developmental and Comparative Immunology·K HálaD L Ewert
May 22, 1992·Brain Research. Developmental Brain Research·M OhnoK Suzuki
Oct 31, 1983·Neuroscience Letters·M R HirschC Goridis
Feb 1, 1985·Journal of Neuroimmunology·G H WongJ W Schrader
Sep 1, 1985·Journal of Neuroimmunology·K SakaiT Tabira
Jan 23, 1999·Journal of Neuroimmunology·M M HiremathG K Matsushima
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P V BastaJ P Ting
Apr 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·N De TriboletM Schreyer
Aug 1, 1984·Journal of Neurosurgery·L P Weiner, J O Fleming
Jan 21, 2011·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jack Antel
Jan 1, 1983·Journal of Neurology·J A Aarli
Jan 1, 1987·Immunobiology·T SminiaC H Polman
Sep 23, 2008·Journal of Neuroimmunology·Meenaxi M HiremathGlenn K Matsushima
Dec 1, 1982·Immunology Today·D F NixonJ A Frelinger
May 1, 1990·Experimental Neurology·I F Pollack, R D Lund
Nov 1, 1989·Clinical Immunology and Immunopathology·N S PeressE Perillo

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