Expression and traffic of cellular prolyl oligopeptidase are regulated during cerebellar granule cell differentiation, maturation, and aging

Neuroscience
M J Moreno-BaylachJ Arturo Garcia-Horsman

Abstract

Prolyl oligopeptidase (POP) is an endopeptidase which cleaves short proline-containing neuropeptides, and it is involved in memory and learning. POP also has an intercellular function mediated through the inositol pathway, and has been involved in cell death. POP has been early considered as a housekeeping enzyme, but the recent research indicates that POP expression is regulated across tissues and intracellularly. In the brain, POP is exclusively expressed in neurons and most abundantly in pyramidal neurons of cerebral cortex, in the CA1 field neurons of hippocampus and in cerebellar Purkinje's cells. Intracellularly, POP is mainly present in the cytoplasm and some in intracellular membranes, like rough endoplasmic reticulum and Golgi apparatus. In this paper, we systematically studied the levels of expression of POP along the life of cerebellar granule cells (CGC) in culture and the distribution of POP within different intracellular compartments. We used the tight-binding inhibitor JTP-4819 covalently coupled with fluorescein (FJTP) as a tool to study the changes on expression and localization of POP protein. Our results indicate that POP activity levels are regulated during the life of the neurons. POP was found mainly in cy...Continue Reading

References

Dec 1, 1987·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P B BellV P Collins
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·C H JiangY Hu
Jan 17, 2002·Neurochemistry International·Jon IrazustaLuis Casis
Mar 28, 2002·Cellular and Molecular Life Sciences : CMLS·L Polgár
Sep 20, 2002·Journal of Medicinal Chemistry·Erik A A WallénJukka Gynther
Aug 7, 2003·Bioorganic & Medicinal Chemistry·Erik A A WallénJukka Gynther
Oct 3, 2003·Journal of Medicinal Chemistry·Erik A A WallénJukka Gynther
Feb 27, 2004·The Journal of Comparative Neurology·Gaelle BellemèreSylvie Jégou
Jun 26, 2004·The Biochemical Journal·Jarkko I VenäläinenPekka T Männistö
Oct 29, 2004·Journal of Medicinal Chemistry·Elina M JarhoErik A A Wallén
Aug 12, 2005·Journal of Neurochemistry·Ingo SchulzSteffen Rossner
Jan 13, 2006·Biochemical Pharmacology·Jarkko I VenäläinenPekka T Männistö
Aug 22, 2006·Bioorganic & Medicinal Chemistry Letters·Elina M JarhoErik A A Wallén
Jan 2, 2007·Neuropeptides·J A García-HorsmanJ I Venäläinen
Apr 25, 2007·Scandinavian Journal of Gastroenterology·J Arturo Garcia-HorsmanPekka T Männistö
Sep 20, 2007·Drug News & Perspectives·Pekka T MännistoJ Arturo García-Horsman

❮ Previous
Next ❯

Citations

Feb 16, 2013·Experimental Brain Research·Yen-Hsun WuMark L Latash
May 6, 2011·Journal of Molecular Histology·Shin MatsubaraAtsushi P Kimura
Jun 29, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Timo T MyöhänenOlli Carpen
Aug 19, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Timo T MyöhänenPekka T Männistö
Jan 28, 2014·International Journal of Medical Sciences·Gorka LarrinagaJosé I López
Sep 13, 2013·Future Medicinal Chemistry·Abraham LópezErnest Giralt
Apr 14, 2011·Neuro-Signals·M José Moreno-BaylachJ Arturo García-Horsman
May 5, 2011·Expert Opinion on Therapeutic Patents·Abraham LópezErnest Giralt
Sep 28, 2010·Biochimica Et Biophysica Acta·Zoltán SzeltnerLászló Polgár
Mar 23, 2010·Journal of Chemical Neuroanatomy·N AgirregoitiaS Jégou
Apr 7, 2010·Regulatory Peptides·Gorka LarrinagaJon Irazusta
Dec 8, 2010·British Journal of Pharmacology·T T MyöhänenP T Männistö
Mar 22, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Corinna HöflingJ Arturo García-Horsman
Jan 1, 2014·Disease Markers·Gorka LarrinagaJosé I López
Nov 1, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Massimo Venditti, Sergio Minucci

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.