PMID: 6400120Dec 1, 1983Paper

Expression at the haemopoietic stem cell level of the genetically determined erythrocyte membrane defects in the Milan hypertensive rat strain (MHS)

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
D TrizioG Bianchi

Abstract

Both humans and rats with essential or genetic arterial hypertension show many alterations of erythrocyte membrane ion transport. The Milan hypertensive rat strain (MHS) has smaller red cells and faster Na+/K+ cotransport across erythrocyte membrane when compared with the control strain (MNS). In order to distinguish if these alterations are due to some inherited cell membrane characteristics or are secondary to some extrinsic factor responsible for hypertension, we have transplanted bone marrow (BM) cells from MHS or MNS rats to two groups of F1 hybrids, lethally irradiated (850 R). Three months after BM transplantation the F1 recipients were killed and their erythrocytes studied. The differences between erythrocytes of F1 MHS BM recipients and F1 MNS BM recipients follow the same pattern described for the donor parental strains. These results indicate that the MHS red cell abnormalities are present in the haemopoietic stem cell and therefore the MHS erythrocyte defects are not due to some extrinsic factors.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.