Expression characteristics of two potential T cell mediator genes

Cellular Immunology
B S KwonM Wakulchik

Abstract

T lymphocyte subset-specific cDNA clones were recently isolated by a modified differential screening procedure. The expression patterns of two of these cDNAs, designated as 4-1BB and L2G25B, were studied in greater detail. Nucleotide sequence comparison revealed that 4-1BB was not previously recognized. Although the L2G25B sequence had been recognized recently, the function of the encoded molecule has yet to be well studied. The transcripts of the two cDNAs were inducible by concanavalin A in mouse spleen cells, cloned helper T cells (L2), cloned cytolytic T cells (L3), and cytolytic T cell hybridomas. They were also inducible with stimulation through antigen receptor (TCR), with immobilized anti-TCR antibody in cloned T cells L2, dB45, and L3. Concanavalin A inducibility was inhibited by cyclosporin A. They were not inducible by IL-2 stimulation. The expression patterns of these transcripts were similar to those of IFN-gamma, except that the level of transcripts of the two cDNAs was at least fivefold lower than that of IFN-gamma, and the peak level of expression occurred earlier. These data suggest that L2G25B and 4-1BB may represent new T cell mediators.

References

Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B S Kwon, S M Weissman
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B S KwonS M Weissman
Jan 1, 1986·Annual Review of Immunology·M KronenbergN Shastri
Jan 1, 1985·Annual Review of Immunology·T Kishimoto
Mar 1, 1983·The Journal of Experimental Medicine·D W LanckiF W Fitch
Apr 1, 1984·Archives of Biochemistry and Biophysics·R HalabanA B Lerner
Oct 1, 1984·Immunological Reviews·D W LanckiF W Fitch
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M KrönkeW C Greene
Dec 1, 1984·The Journal of Experimental Medicine·A Granelli-PipernoR M Steinman
Jan 1, 1984·Annual Review of Immunology·K A Smith
Jul 1, 1984·The Journal of Experimental Medicine·P A HenkartM P Henkart
Apr 1, 1980·The Journal of Experimental Medicine·A L Glasebrook, F W Fitch
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y KaufmannZ Eshhar

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Citations

May 14, 2005·Cancer Immunology, Immunotherapy : CII·Adam T C CheukBarbara-ann Guinn
Feb 25, 2011·Molecules and Cells·Jung D KimByoung S Kwon
Feb 1, 1995·Immunology Letters·Z ZhouB S Kwon
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N J ChalupnyA Aruffo
Mar 1, 1995·The Journal of Experimental Medicine·M A DeBenedetteT H Watts
Mar 10, 1998·AIDS Research and Human Retroviruses·S WangB S Kwon
Oct 1, 1996·Immunobiology·A HaelensJ van Damme
Apr 4, 2017·British Journal of Pharmacology·A C Foks, J Kuiper
Dec 13, 2003·Cancer Gene Therapy·Adam T C CheukBarbara-ann Guinn
May 1, 1991·Cytokine·T J Schall

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